Neurobiology
Purpose of Course showclose
Course Information showclose
Course Designer: Kathleen George
Primary Resources: This course is comprised of a range of different free, online materials. However, the course makes primary use of the following materials:
- The University of Texas: Neuroscience Online
- Biologymad.com: Nervous System
- NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al.’s (ed.) Neuroscience, 2nd Edition
In order to “pass” this course, you will need to earn a 70% or higher on the Final Exam. Your score on the exam will be tabulated as soon as you complete it. If you do not pass the exam, you may take it again.
Time Commitment: This course is the equivalent of a 3-credit semester long course, and should take you approximately 121.5 hours to complete. Unit 1 is primarily background, so may be completed in less time than other sections. Each unit includes a “time advisory” that lists the amount of time you are expected to spend on each subunit. These should help you plan your time accordingly. It may be useful to take a look at these time advisories and to determine how much time you have over the next few weeks to complete each unit, and then to set goals for yourself. For example, Unit 1 should take you 6 hours. Perhaps you can sit down with your calendar and decide to complete subunits 1.1 and 1.2 (a total of 2 hours) on Monday night; subunit 1.3 (a total of 2 hours) on Tuesday night; etc.
Tips/Suggestions: Neurobiology can be very difficult to learn! We have attempted to provide you with, in our opinion, the best free Internet resources to facilitate your learning of the concepts. It will be helpful to take copious notes as you review each topic. These notes will be great to review as you prepare for your final exam.
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This course features a number of Khan Academy™ videos. Khan Academy™ has a library of over 3,000 videos covering a range of topics (math, physics, chemistry, finance, history and more), plus over 300 practice exercises. All Khan Academy™ materials are available for free at www.khanacademy.org.
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Learning Outcomes showclose
- demonstrate an understanding of the basic biochemical concepts pertinent to cell biology;
- identify the basic structure of the nerve cell, the various functions of different components of the nerve cells, and different types of nerve cells;
- describe various different nervous systems;
- describe the structure and function of the nervous systems;
- explain how nerve cells propagate and transmit nervous impulses;
- describe select diseases caused by malfunctioning or nerve cell death in parts of the nervous system;
- explain how the nervous system responds to nerve damage or death and therapeutic measures;
- describe how the nervous system is formed in the embryo and identify the role of various genes and hormonal regulators in that development process;
- describe the structure and function of the brain and spinal cord; and
- describe the structure and function of the somatic sensory system and the motor system.
Course Requirements showclose
√ have access to a computer;
√ have continuous broadband internet access;
√ have the ability/permission to install plug-ins or software (e.g. Adobe ReaderorFlash);
√ have the ability to download and save files and documents to a computer;
√ have the ability to open Microsoft files and documents (.doc, .ppt, .xls, etc.);
√ be competent in the English language;
√ have read the Saylor Student Handbook; and
√ have completed the following courses listed in “The Core Program” of the Biology discipline as pre-requisites: BIO101: Introduction to Molecular and Cellular Biology and BIO301: Cell Biology; BIO302: Human Anatomy (Unit 5 Nervous System).Unit Outline show close
Expand All Resources Collapse All Resources
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Unit 1: Basic Concepts and Introduction
In our first unit of neurobiology, we will review some of the fundamental concepts of chemistry and biology that you will need to know prior to learning new material in this course. This unit will also introduce to you the general anatomy and function of neurobiology, from the individual neurons to global control systems. This introduction is designed to help you keep track of how individual topics you will learn about in this course relate to the larger picture.
Unit 1 Time Advisory show close
Unit 1 Learning Outcomes show close
- 1.1 Chemistry Principles
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1.1.1 Chemical Bonds (Polar, Covalent, Ionic, etc.)
- Reading: Georgia State University: Hyperphysics’ “Chemical Bonding”
Link: Georgia State University: Hyperphysics’ “Chemical Bonding” (HTML)
Instructions: Click on “Chemistry” on the right margin, then click on the bubble for “Chemical Bonding,” and select any bubble for the chemical bond shown on the webpage to read about it. While this course is not a chemistry course, it is important to understand basic chemistry principles, such as chemical bonds and ionic charges, in order to learn neurobiology concepts, such as action potential and neurotransmission.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Georgia State University: Hyperphysics’ “Chemical Bonding”
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1.1.2 Cations and Anions
- Reading: Online Introductory Chemistry: Dr. Volland’s “Ions and Prediction of Ionic Charges”
Link: Online Introductory Chemistry: Dr. Volland’s “Ions and Prediction of Ionic Charges” (HTML)
Instructions: Read the entire webpage linked above.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Online Introductory Chemistry: Dr. Volland’s “Ions and Prediction of Ionic Charges”
- 1.2 Biology Concepts
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1.2.1 Action Potential
- Web Media: YouTube: rhabib’s “Action Potential”
Link: YouTube: rhabib’s “Action Potential” (YouTube)
Instructions: Watch this is introductory video for some background information on action potentials. This concept will be more fully covered in subunit 2.2.
Watching this video should take approximately 1 hour 30 minutes.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Web Media: YouTube: rhabib’s “Action Potential”
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1.2.2 Cell Organelles
- Web Media: YouTube: Hilliard1sm’s “Eukaryotic Cell and Organelle Photostory”
Link: YouTube: Hilliard1sm’s “Eukaryotic Cell and Organelle Photostory” (YouTube)
Instructions: Watch the video linked above.
Watching this video should take approximately 5 minutes.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Web Media: YouTube: Hilliard1sm’s “Eukaryotic Cell and Organelle Photostory”
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1.2.3 Central Dogma of Biology
- Reading: AccessExcellence’s “The Central Dogma of Biology”
Link: AccessExcellence’s “The Central Dogma of Biology” (HTML)
Instructions: Read the entire webpage for information on the four steps of the Central Dogma: Replication of DNA, transcription of DNA to mRNA, processing of mRNA, and translation of mRNA to protein. Make sure to view the image carefully, and click any embedded hyperlinks in the “Legend” section for more information.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Web Media: YouTube: FreeScienceLectures.com’s “DNA Replication Process” and YouTube: redandbrownpaperbag’s “DNA Transcription and Protein Assembly”
Links: YouTube: FreeScienceLectures.com’s “DNA Replication Process” (YouTube) and YouTube: redandbrownpaperbag’s “DNA Transcription and Protein Assembly” (YouTube)
Instructions: Watch both videos linked above.
Watching these brief videos should take approximately 6 minutes.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: AccessExcellence’s “The Central Dogma of Biology”
- 1.3 Introduction to Nervous System Cells
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1.3.1 Neurons
- Reading: How Stuff Works: Dr. Craig Freudenrich and Robynne Boyd’s “How Your Brain Works”
Link: How Stuff Works: Dr. Craig Freudenrich and Robynne Boyd’s “How Your Brain Works” (HTML)
Instructions: Read sections 1-3 of this webpage for an overview of the science behind how the human brain functions.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: How Stuff Works: Dr. Craig Freudenrich and Robynne Boyd’s “How Your Brain Works”
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1.3.2 Neuroglia Cells
- Reading: The University of Texas’s Neuroscience Online: Jack Waymire’s “Ch 8: Organization of Cell Types”
Link: The University of Texas’s Neuroscience Online: Jack Waymire’s “Ch 8: Organization of Cell Types” (HTML)
Instructions: Read the entire webpage linked above.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Jack Waymire’s “Ch 8: Organization of Cell Types”
- 1.4 Introduction to Neural Organization
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1.4.1 Neural Circuits
- Reading: NCBI Bookshelf s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 1: The Organization of the Nervous System - Neural Circuits”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 1: The Organization of the Nervous System - Neural Circuits” (HTML)
Instructions: Read the entire webpage linked above.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 1: The Organization of the Nervous System - Neural Circuits”
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1.4.2 Central Nervous System (CNS)
- Reading: eMedicine Health: Fernando Dangond’s “Central Nervous System Overview”
Link: eMedicine Health: Fernando Dangond’s “Central Nervous System Overview” (HTML)
Instructions: Read the section titled “Anatomy of the Central Nervous System” (pages 1-3 only). You may want to click on any embedded hyperlinks for definitions of terms and concepts.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: eMedicine Health: Fernando Dangond’s “Central Nervous System Overview”
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1.4.3 Peripheral Nervous System (PNS)
Note: This unit is covered by the reading for 1.4.2.
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1.4.4 Effectors and Stimuli
- Reading: PMR Science: Zhi Yan’s “Sensory Organs and Their Functions”
Link: PMR Science: Zhi Yan’s “Sensory Organs and Their Functions” (HTML)
Also available in:
PDF
Instructions: Read the entire webpage linked above.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: PMR Science: Zhi Yan’s “Sensory Organs and Their Functions”
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1.4.5 Neuroanatomical Terminology
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 1: Some Anatomical Terminology”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’Neuroscience 2nd Edition: “Ch 1: Some Anatomical Terminology” (HTML)
Instructions: Read the entire webpage, and explore the hyperlinks to Figure 1.9. Which way is up? Simple as this question might seem, you can get different answers if you are upside down or upright. To eliminate ambiguity in phrasing, biologists have developed specialized terms (i.e. superior and anterior) to help you accurately define the location of body parts in relation to one another. It is very important that you know these terms so that you will be able to trace paths or learning positions more easily.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: PBS: “The Secret Life of the Brain: 3-D Brain Anatomy”
Link: PBS: “The Secret Life of the Brain: 3-D Brain Anatomy” (Adobe Shockwave)
Instructions: Follow the instructions on the webpage to view the neuroanatomy of the brain.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.
Note: Which way is up? Simple as this question might seem, you can get different answers if you are upside down or upright. To eliminate ambiguity in phrasing, biologists have developed specialized terms (i.e. superior and anterior) to help you accurately define the location of body parts in relation to one another. It is very important that you know these terms so that you will be able to trace paths or learning positions more easily.See a broken link? Please let us know!
- Assessment: The Saylor Foundation’s “Unit 1 Assessment”
Link: The Saylor Foundation’s “Unit 1 Assessment” (PDF)
Instructions: Complete this quiz after working through Unit 1. The questions are multiple choice, matching, or labeling diagrams. You can check your answers with The Saylor Foundation’s “Unit 1 Assessment Answer Key” (PDF).See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 1: Some Anatomical Terminology”
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Unit 2: Electrical Signaling
Our nervous system is amazingly responsive and powerful when reacting to information about the body and its environment. If you touch a very hot object, you instantly feel pain and automatically withdraw your hand. The entire process, from heat sensation to the coordination of motor function, happens within milliseconds–in other words, faster than you can consciously think! This type of speed requires a very fast and strong signaling method known as electrical signaling. This unit explains this process in detail, teaching you how signaling is generated and how it is propagated. You will also learn about a few devastating diseases that occur when the process is compromised.
Unit 2 Time Advisory show close
Unit 2 Learning Outcomes show close
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2.1 Electric Potential
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2.1.1 Resting Membrane Potential
- Web Media: YouTube: Great Pacific Media’s “The Nervous System: Neurons, Networks, and the Human Brain’s ‘Neuron Resting Potential’”
Link: YouTube: Great Pacific Media’s “The Nervous System: Neurons, Networks, and the Human Brain’s ‘Neuron Resting Potential’” (YouTube)
Instructions: Watch this video about key components of the nervous system. This resource covers subsections 2.1.1 and 2.1.2.
Watching this video should take approximately 4 minutes.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Web Media: Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 4th Edition: “Animation 2.1: The Resting Membrane Potential”
Link: Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 4th Edition: “Animation 2.1: The Resting Membrane Potential” (Adobe Flash)
Instructions: Watch the entire animation. To begin, either click on “Step Through” or “Narrated.” Then, click the play button on the webpage to begin the video.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Web Media: YouTube: Great Pacific Media’s “The Nervous System: Neurons, Networks, and the Human Brain’s ‘Neuron Resting Potential’”
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2.1.2 Relative Ion Concentrations
Note: This topic is covered by the video beneath subunit 2.1.1.
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2.1.3 Nernst Equation and Ionic Basis of Electrical Potential
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “The Forces that Create Membrane Potentials” and “The Ionic Basis of the Resting Membrane Potential”
Links: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “The Forces that Create Membrane Potentials” (HTML) and “The Ionic Basis of the Resting Membrane Potential” (HTML)
Instructions: Read both webpages, click on any embedded hyperlinks, and explore the figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Web Media: YouTube: LLKeeley’s “4. Nernst Equation and Calculations of Membrane Potentials”
Link: YouTube: LLKeeley’s “4. Nernst Equation and Calculations of Membrane Potentials” (YouTube)
Instructions: Watch this video for a brief introduction to calculating cell membrane potentials. Take some time to take notes on the formula provided.
Watching this video should take approximately 4 minutes.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “The Forces that Create Membrane Potentials” and “The Ionic Basis of the Resting Membrane Potential”
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2.1.4 Ion Channels
- Web Media: YouTube: Diane K. O'Dowd’s “Membrane Potential”
Link: YouTube: Diane K. O'Dowd’s “Membrane Potential” (YouTube)
Instructions: Watch this video that provides a visual explanation of membrane potential.
Watching this video should take approximately 2 minutes.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Web Media: YouTube: Diane K. O'Dowd’s “Membrane Potential”
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2.2 Action Potential
- Reading: W.H Freeman & Co.: Life -- The Science of Biology (7th ed.): “Chapter 44: The Action Potentials”
Link: W.H Freeman & Co.: Life --The Science of Biology (7th ed.): “Chapter 44: The Action Potentials” (HTML and Adobe Flash)
Instructions: Click on each tab for “The resting membrane potential,” and read or listen to its contents. Then, navigate to “page 2,” click on each tab for “The action potential,” and read or listen to its contents.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: W.H Freeman & Co.: Life -- The Science of Biology (7th ed.): “Chapter 44: The Action Potentials”
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2.2.1 Voltage-Dependent Currents
- Web Media: YouTube: Garland Science’s “Action Potential” and 1Lecture.com’s “Action Potential Propagation in an Unmyelinated Axon”
Link: YouTube: Garland Science’s “Action Potential” (YouTube) and 1Lecture.com’s “Action Potential Propagation in an Unmyelinated Axon” (Adobe Flash)
Instructions: Watch the linked videos above.
Watching these videos should take approximately 5 minutes.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Web Media: YouTube: Garland Science’s “Action Potential” and 1Lecture.com’s “Action Potential Propagation in an Unmyelinated Axon”
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2.2.2 Sodium and Potassium Channels
- Web Media: YouTube: APBio Tutorials’ “Nerve Impulse”
Link: YouTube: APBio Tutorials’ “Nerve Impulse” (YouTube)
Instructions: Watch the video linked above to learn how sodium and potassium channels function during a nerve impulse.
Watching this video should take approximately 2 minutes.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Web Media: YouTube: APBio Tutorials’ “Nerve Impulse”
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2.2.3 Squid Cell Example
- Web Media: YouTube: Alan Hodgkin’s “Action Potential from Squid”
Link: YouTube: Alan Hodgkin’s “Action Potential from Squid” (YouTube)
Instructions: Watch the video linked above.
Watching this video should take approximately 5 minutes.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Web Media: YouTube: Alan Hodgkin’s “Action Potential from Squid”
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2.2.4 Threshold
- Reading: The University of Texas’s Neuroscience Online: Professor John Byrne’s “Ch 1: Resting Potentials and Action Potentials”
Link: The University of Texas’s Neuroscience Online: Professor John Byrne’s “Ch 1: Resting Potentials and Action Potentials” (HTML and Adobe Flash)
Instructions: Read the following sections: “Introduction to the Action Potential,” “Intracellular Recordings from Neurons,” and “Components of the Action Potential.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Professor John Byrne’s “Ch 1: Resting Potentials and Action Potentials”
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2.2.5 Depolarization
Note: This topic is covered in the reading assigned beneath subunit 2.2.4.
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2.2.6 Refractory Period
- Reading: Biologymad.com: “Nervous System – Nerve Impulses”
Link: Biologymad.com: “Nervous System – Nerve Impulses” (HTML)
Instructions: Click on the hyperlink titled “Propagation of Impulses,” and read the section “How are nerve impulses propagated?”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Biologymad.com: “Nervous System – Nerve Impulses”
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2.2.7 All-or-None Principle
- Reading: Biologymad.com: “Nervous System – Nerve Impulses”
Link: Biologymad.com: “Nervous System – Nerve Impulses” (HTML)
Instructions: Click on the hyperlink titled “Action Potential.” Then, scroll down the webpage until you reach the section titled “All or Nothing Law,” and read this entire section.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Biologymad.com: “Nervous System – Nerve Impulses”
- 2.3 Ion Channels and Transporters
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2.3.1 Channel vs. Transporter
- Reading: What Is Life: Lukas K. Buehler’s “Bioelectricity of Cell Membranes”
Link: What Is Life: Lukas K. Buehler’s “Bioelectricity of Cell Membranes” (HTML)
Instructions: Click on the hyperlink titled “Membrane Currents,” and read the entire section to understand how channels and transporters work together.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: What Is Life: Lukas K. Buehler’s “Bioelectricity of Cell Membranes”
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2.3.2 Voltage-gated Ion Channels
- Web Media: 1Lecture.com: “Voltage-Gated Channels and the Action Potential”
Link: 1Lecture.com: “Voltage-Gated Channels and the Action Potential” (Adobe Flash)
Instructions: Watch the video linked above.
Watching this video should take approximately 3 minutes.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Web Media: 1Lecture.com: “Voltage-Gated Channels and the Action Potential”
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2.3.3 Ligand-gated Ion Channels
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ligand-Gated Ion Channels”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ligand-Gated Ion Channels” (HTML)
Instructions: Read the entire webpage and click on the hyperlinks to the figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ligand-Gated Ion Channels”
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2.3.4 Other Ion Channels
- Reading: What Is Life: Lukas K. Buehler’s “Bioelectricity of Cell Membranes”
Link: What Is Life:Lukas K. Buehler’s “Bioelectricity of Cell Membranes” (HTML)
Instructions: Click on the hyperlink titled “Synaptic Transmission,” and read the entire section to learn about the role of other ion channels in the nerve cell.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: What Is Life: Lukas K. Buehler’s “Bioelectricity of Cell Membranes”
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2.3.5 Specificity of Ion Channels
- Reading: What Is Life: Lukas K. Buehler’s “Bioelectricity of Cell Membranes”
Link: What Is Life: Lukas K. Buehler’s “Bioelectricity of Cell Membranes” (HTML)
Instructions: Click on the hyperlink for “Ion Selectivity,” and read the entire section. Ion channels can be remarkably specific and non-specific,depending on their purpose for the body. For example, potassium channels used in action potential are highly specific to potassium and will not allow other ions to sneak through. This is largely due to the thermodynamic properties of the channel, which is in turn based on the structure of the channel itself. Be sure to understand this connection, noting how structure determines specificity!
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.
See a broken link? Please let us know!
- Reading: What Is Life: Lukas K. Buehler’s “Bioelectricity of Cell Membranes”
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2.3.6 Transport and Maintenance of Potential
- Reading: Biologymad.com: “Nervous System – Nerve Impulses”
Link: Biologymad.com: “Nervous System – Nerve Impulses” (HTML)
Instructions: Click on the hyperlink for “Resting Membrane Potential,” and read this section to understand how membrane potential is maintained.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Biologymad.com: “Nervous System – Nerve Impulses”
- 2.4 Propagation of Signal
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2.4.1 Bidirectional
- Web Media: YouTube: Khan Academy’s “Neuronal Synapses”
Link: YouTube: Khan Academy’s “Neuronal Synapses” (YouTube)
Also available in:
iTunes U
Instructions: Watch the video linked above
Watching this video should take approximately 20 minutes.
Terms of Use: This video is licensed under a Creative Commons Attribution-NonCommercial-NoDerives United States License 3.0. It is attributed to the Khan Academy.See a broken link? Please let us know!
- Web Media: YouTube: Khan Academy’s “Neuronal Synapses”
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2.4.2 Unidirectional
- Reading: Biologymad.com: “Nervous System – Nerve Impulses”
Link: Biologymad.com: “Nervous System – Nerve Impulses” (HTML)
Instructions: Click on the hyperlink titled “Propagation of Impulses,” and read the entire section. Although we saw this resource in section 2.3.6, work through this content again, paying attention to how the membrane potential over the entire nerve serves to propagate nerve impulses.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Biologymad.com: “Nervous System – Nerve Impulses”
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2.4.3 Myelin and Nodes of Ranvier
- Reading: What Is Life: Lukas K. Buehler’s “Bioelectricity of Cell Membranes”
Link: What Is Life: Lukas K. Buehler’s “Bioelectricity of Cell Membranes” (HTML)
Instructions: Click on the hyperlink “Axonal Propagation and Myelination,” and read the entire section.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: What Is Life: Lukas K. Buehler’s “Bioelectricity of Cell Membranes”
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2.4.4 Saltatory Conduction
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 3: Increased Conduction Velocity as a Result of Myelination”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc.,Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 3: Increased Conduction Velocity as a Result of Myelination” (HTML)
Instructions: Read this section of Chapter 3, click on any embedded hyperlinks, and make sure to click on the figures at the end of the text to enlarge and explore them.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Web Media: Khan Academy’s “Saltatory Conduction in Neurons”
Link: Khan Academy’s “Saltatory Conduction in Neurons” (Adobe Flash)
Also available in:
iTunes U
Instructions: Watch the video linked above.
Watching this video should take approximately 12 minutes.
Terms of Use: This video is licensed under a Creative Commons Attribution-NonCommercial-NoDerives United States License 3.0. It is attributed to the Khan Academy.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 3: Increased Conduction Velocity as a Result of Myelination”
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2.4.5 Safety Factor
- Reading: The University of Texas’s Neuroscience Online: Dr. John Byrne’s “Ch 4: Synaptic Transmission and the Skeletal Neuromuscular Junction”
Link: The University of Texas’s Neuroscience Online: Dr. John Byrne’s “Ch 4: Synaptic Transmission and the Skeletal Neuromuscular Junction” (HTML)
Instructions: Read the section on the “Physiology of Synaptic Transmission at the Neuromuscular Junction.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. John Byrne’s “Ch 4: Synaptic Transmission and the Skeletal Neuromuscular Junction”
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2.4.6 Synapse
- Reading: Biologymad.com: “Nervous System: Synapses”
Link: Biologymad.com: “Nervous System: Synapses” (HTML)
Instructions: Click on and read the section titled “Different Types of Synapses.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Biologymad.com: “Nervous System: Synapses”
- 2.5 Diseases of Electrical Signaling
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2.5.1 Tetrodotoxin
- Reading: The University of Texas’s Neuroscience Online: Dr. John Byrne’s “Ch 4: Synaptic Transmission and the Skeletal Neuromuscular Junction” and “Ch 2: Ionic Mechanisms and Action Potentials”
Links: The University of Texas’s Neuroscience Online: Dr. John Byrne’s “Ch 4: Synaptic Transmission and the Skeletal Neuromuscular Junction” (HTML) and “Ch 2: Ionic Mechanisms and Action Potentials” (HTML)
Instructions: Click on the first link above, then scroll down to section 4.7 to read about the “Iontophoresis of ACh.” Then, click the second link posted above, and scroll down to section 2.5 to read about the “Pharmacology of the Voltage-Dependent Membrane Channels.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. John Byrne’s “Ch 4: Synaptic Transmission and the Skeletal Neuromuscular Junction” and “Ch 2: Ionic Mechanisms and Action Potentials”
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2.5.2 Multiple Sclerosis
- Reading: Imaginis: “What Causes Multiple Sclerosis?”
Link: Imaginis: “What Causes Multiple Sclerosis?” (HTML)
Instructions: Read the webpage linked above.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Web Media: YouTube: mPenn1’s “What Is Multiple Sclerosis?”
Link: YouTube: mPenn1’s “What Is Multiple Sclerosis?” (YouTube)
Instructions: Watch the video linked above
Watching this video should take approximately 2 minutes.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Imaginis: “What Causes Multiple Sclerosis?”
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2.5.3 Channelopathies
- Reading: The University of Texas’s Neuroscience Online: Dr. John Byrne’s “Ch 2: Ionic Mechanisms and Action Potentials”
Link: The University of Texas’s Neuroscience Online: Dr. John Byrne’s “Ch 2: Ionic Mechanisms and Action Potentials” (HTML)
Instructions: Read the section on “Channelopathies.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Assessment: The Saylor Foundation’s “Unit 2 Assessment”
Link: The Saylor Foundation’s “Unit 2 Assessment” (PDF)
Instructions: Complete this quiz after working through Unit 2. The questions are multiple choice, matching, or labeling diagrams. You can check your answers with The Saylor Foundation’s “Unit 2 Assessment Answer Key” (PDF).See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. John Byrne’s “Ch 2: Ionic Mechanisms and Action Potentials”
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Unit 3: Synapses and Neurotransmitters
Returning to our example of heat sensation and the reflexes it elicits, we will now look at synapses and neurotransmitters. Synapses are the communication links between neurons or between neurons and other cells. The human brain alone contains more than 100 billion neurons, and each of those neurons contains numerous synapses, multiplying to a mind-boggling number of neural connections. This unit will first examine the two major types of synapses: electrical and chemical. Compared to electrical synapses, chemical synapses are slower, more varied, and offer signal amplification. We will also learn that, because most neurons have a number of synapses, there are also regulatory pathways that prevent signaling confusion. Lastly, we will cover neurotransmitters, agents produced by the presynaptic cell that initiate actions for the postsynaptic cell.
Unit 3 Time Advisory show close
Unit 3 Learning Outcomes show close
- 3.1 Overview of Synapses
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3.1.1 Presynaptic and Postsynaptic Elements
- Reading: Biologymad.com: “Nervous System – Synapses”
Link: Biologymad.com: “Nervous System – Synapses” (HTML)
Instructions: Click on the link above, then on the section titled “Synapses,” and read the contents of this webpage. This webpage also covers sections 3.3.1 and 3.3.2
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Biologymad.com: “Nervous System – Synapses”
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3.1.2 Directionality
- Reading: Biologymad.com: “Nervous System – Synapses”
Link: Biologymad.com: “Nervous System – Synapses” (HTML)
Instructions: Click on and read the section titled: “So why bother? Why have gaps in nerves?”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Biologymad.com: “Nervous System – Synapses”
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3.1.3 Electrical Synapse Members
- Reading: Absolute Astronomy.com: “Electrical Synapse”
Link: Absolute Astronomy.com: “Electrical Synapse” (HTML)
Instructions: Read the entire webpage linked above.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Absolute Astronomy.com: “Electrical Synapse”
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3.1.4 Chemical Synapse Members
- Web Media: 1Lecture.com: McGraw-Hill’s “Chemical Synapse”
Link: 1Lecture.com: McGraw-Hill’s “Chemical Synapse” (Adobe Flash)
Instructions: Watch the video linked above.
Watching this video should take approximately 2 minutes.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Web Media: 1Lecture.com: McGraw-Hill’s “Chemical Synapse”
- 3.2 Electrical Synapse
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3.2.1 Conduction Link
- Reading: Consortium on Cognitive Science Instruction: Robert Stufflebeam’s “Neurons, Synapses, Action Potential, and Neurotranmission”
Link: Consortium on Cognitive Science Instruction: Robert Stufflebeam’s “Neurons, Synapses, Action Potential, and Neurotranmission” (HTML and Adobe Flash)
Instructions: Read the “Conduction” paragraph in the reading linked above.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Consortium on Cognitive Science Instruction: Robert Stufflebeam’s “Neurons, Synapses, Action Potential, and Neurotranmission”
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3.2.2 Gap Junctions
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 5: Electrical Synapses”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 5: Electrical Synapses” (HTML)
Instructions: Read the entire webpage, exploring the hyperlinks to figures. This reading also covers section 3.2.3.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 5: Electrical Synapses”
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3.2.3 Synaptic Delay
Note: This topic is covered by the reading under subunit 3.2.2.
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3.2.4 Ion Flow
- Reading: Nature Education: Scitable’s “Ion Channel”
Link: Nature Education: Scitable’s “Ion Channel” (HTML)
Instructions: Read the first two sections, and study figure 1 after the second paragraph.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Nature Education: Scitable’s “Ion Channel”
- 3.3 Chemical Synapses
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3.3.1 Synaptic Cleft
- Web Media: Human Anatomy (Online Learning Center): “Animation: Chemical Synapse”
Link: Human Anatomy (Online Learning Center): “Animation: Chemical Synapse” (Adobe Flash)
Instructions: Watch the linked video above. This covers sections 3.3.1 and 3.3.2.
Watching this video should take approximately 2 minutes.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Web Media: Human Anatomy (Online Learning Center): “Animation: Chemical Synapse”
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3.3.2 Synaptic Vesicles and Neurotransmitters
Note: This topic is covered by the animation under subunit 3.3.1.
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3.3.3 Quantal Transmitter Release
- Reading: The University of Texas’s Neuroscience Online: Dr. John Byrne’s “Ch 5: Mechanisms of Neurotransmitter Release: Role of Calcium in Transmitter Release”
Link: The University of Texas’s Neuroscience Online: Dr. John Byrne’s “Ch 5: Mechanisms of Neurotransmitter Release: Role of Calcium in Transmitter Release” (HTML)
Instructions: Read the section on “Quantal Nature of Transmitter Release.” This also covers sections 3.3.4 and 3.3.5.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. John Byrne’s “Ch 5: Mechanisms of Neurotransmitter Release: Role of Calcium in Transmitter Release”
-
3.3.4 Recycling of Vesicles
Note: This topic is covered by the reading under subunit 3.3.3.
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3.3.5 Role of Calcium
Note: This topic is covered by the reading under subunit 3.3.3.
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3.3.6 Postsynaptic Membrane Permeability Change
- Reading: Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 7: Neurotransmitter Receptor Alter Postsynaptic Membrane Permeability”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 7: Neurotransmitter Receptor Alter Postsynaptic Membrane Permeability” (HTML)
Instructions: Read the entire webpage linked above.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 7: Neurotransmitter Receptor Alter Postsynaptic Membrane Permeability”
- 3.4 Synaptic Crosstalk
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3.4.1 Inhibitory Postsynaptic Potential
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 7: Excitatory and Inhibitory Postsynaptic Potentials”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 7: Excitatory and Inhibitory Postsynaptic Potentials” (HTML)
Instructions: Read the entire webpage, click on any embedded hyperlinks, and explore the figures. This reading also covers subunit 3.4.2.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 7: Excitatory and Inhibitory Postsynaptic Potentials”
-
3.4.2 Excitatory Postsynaptic Potential
Note: This topic is covered by the reading under subunit 3.4.1.
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3.4.3 Summation of Potentials
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 7: Summation of Synaptic Potentials”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 7: Summation of Synaptic Potentials” (HTML)
Instructions: Read the entire webpage, click on any embedded hyperlinks, and explore the figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 7: Summation of Synaptic Potentials”
- 3.5 Neurotransmitter (NT) Categories
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3.5.1 Neurotransmitter Synthesis
- Reading: NCBI Bookshelf’ version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 6: Neurotransmitter Synthesis”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 6: Neurotransmitter Synthesis” (HTML)
Instructions: Read the entire webpage, click on any embedded hyperlinks, and explore the figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’ version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 6: Neurotransmitter Synthesis”
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3.5.2 Acetylcholine
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 6: Acetylcholine”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 6: Acetylcholine” (HTML)
Instructions: Read the entire webpage, click on the embedded hyperlinks, and explore the figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Web Media: Sinauer Associates, Inc., Neuroscience 4th Edition: “Animation 6.1 Neurotransmitter Pathways: Acetylcholine”
Link: Sinauer Associates, Inc., Neuroscience 4th Edition: “Animation 6.1 Neurotransmitter Pathways: Acetylcholine” (Abobe Flash)
Instructions: Watch the animation linked above. Click on Step-Through or Narrated to begin the animation, and then follow the instructions on the webpage to work through “Synthesis,” “Distribution,” and “Pharmacology.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 6: Acetylcholine”
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3.5.3 Amino Acids
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 6: GABA and Glycine” and “Glutamate”
Links: NCBI Bookshelf’sversion of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 6: GABA and Glycine” (HTML) and “Glutamate” (HTML)
Instructions: Read the both webpages in their entirety, click on any embedded hyperlinks, and explore all figures. In addition to standard amino acids like glycine and glutamate, this category also includes GABA (gamma-aminobutyric acid). GABA is a very important NT—you should know about its functions!
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 6: GABA and Glycine” and “Glutamate”
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3.5.4 Biogenic Amines
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 6: The Biogenic Amines”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 6: The Biogenic Amines” (HTML)
Instructions: Read the entire webpage, click on any embedded hyperlinks, and explore all figures. This category includes a functionally diverse but similarly-structured group comprised of dopamine, epinephrine, histamine, and serotonin. Be sure to know the differences between these molecules!
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 6: The Biogenic Amines”
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3.5.5 Neuropeptides
- Reading: Neuropeptides.net: All about Neuropeptides.
Link: Neuropeptides.net: All about Neuropeptides (HTML)
Instructions: Read the entire webpage to learn about the function, characteristics, and benefits of neuropeptides.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 6: Neuropeptides Figure”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 6: Neuropeptides Figure” (HTML)
Instructions: Please review the figure of neuropeptides on this webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Neuropeptides.net: All about Neuropeptides.
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3.5.6 ATP
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 6: ATP and Other Purines”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 6: ATP and Other Purines” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 6: ATP and Other Purines”
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3.5.7 Nitric Oxide
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 8: Second Messenger”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 8: Second Messenger” (HTML)
Instructions: Scroll down and read the paragraph for “Nitric Oxide.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience 2nd Edition: “Ch 8: Second Messenger”
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3.5.8 Cannabinoid
- Reading: Oxford Journals: Brain – A Journal of Neurobiology: Leslie Iversen’s “Cannabis and the Brain”
Link: Oxford Journals: Brain – A Journal of Neurobiology: Leslie Iversen’s “Cannabis and the Brain” (HTML)
Also available in:
PDF
Instructions: Read the entire webpage linked above.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Oxford Journals: Brain – A Journal of Neurobiology: Leslie Iversen’s “Cannabis and the Brain”
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3.6 Neurotrophin Receptor Families
- Web Media: Sinauer Associates, Inc: Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 4th Ed.: “Ch 5 – Ionotropic and Metatropic Receptors”
Link: Sinauer Associates, Inc.: Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 4th Ed.: “Ch 5 – Ionotropic and Metatropic Receptors” (Adobe Flash)
Instructions: Click the “narrated” link, and watch the animation. This resource also covers sections 3.6.1 and 3.6.2.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Web Media: Sinauer Associates, Inc: Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 4th Ed.: “Ch 5 – Ionotropic and Metatropic Receptors”
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3.6.1 Ionotropic Receptors

Note: This topic is covered by the animation linked under subunit 3.6.
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3.6.2 Metabotropic Receptor Family
Note: This topic is covered by the animation linked under subunit 3.6.
- Assessment: The Saylor Foundation’s “Unit 3 Assessment”
Link: The Saylor Foundation’s “Unit 3 Assessment” (PDF)
Instructions: Complete this quiz after working through Unit 3. The questions are either multiple choice, matching, or labeling diagrams. Your answers can be checked against The Saylor Foundation’s “Unit 3 Assessment Answer Key” (PDF).
Completing this assessment should take approximately 30 minutes.See a broken link? Please let us know!
- Assessment: The Saylor Foundation’s “Unit 3 Assessment”
-
Unit 4: Neural Plasticity and Repair
Plasticity is the process by which neurons change and connect as a result of new experiences. It is most evident in infancy and childhood, where the growing brain will rapidly learn new skills and acquire knowledge. The adult brain, although less able to adapt, is able to form new memories throughout its lifetime thanks to plasticity. Neural repair reshapes connections, though this process is much more varied. Researchers continue to deepen their appreciation for the importance of plasticity in adults as they seek clues as to how the brain and spinal cord recover from injury. This unit will study plasticity in growing and injured neurons and discuss the leading theories explaining how neurons adapt.
Unit 4 Time Advisory show close
Unit 4 Learning Outcomes show close
- 4.1 Critical Periods
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4.1.1 Language Development
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 24: The Development of Language: A Critical Period in Humans”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 24: The Development of Language: A Critical Period in Humans” (HTML)
Instructions: Read the webpage linked above.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 24: The Development of Language: A Critical Period in Humans”
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4.1.2 Visual System Development
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 24: Critical Periods of Visual System Development”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 24: Critical Periods of Visual System Development” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.
See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 24: Critical Periods of Visual System Development”
- 4.2 Hebb’s Postulate
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4.2.1 Long-term Potentiation
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 25: Long-term Synaptic Potentiation”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 25: Long-term Synaptic Potentiation” (HTML)
Instructions: Read the entire webpage linked above.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 25: Long-term Synaptic Potentiation”
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4.2.2 Cooperation and Competition
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 24: Mechanism by Which Neuronal Activity Affects the Development of Neural Circuits”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 24: Mechanism by Which Neuronal Activity Affects the Development of Neural Circuits” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 24: Mechanism by Which Neuronal Activity Affects the Development of Neural Circuits”
- 4.3 Neuronal Death in Injury
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4.3.1 Apoptosis and Necrosis
- Reading: Reading: The University of Texas’s Neuroscience Online: Dr. Pramod Dash’s “Ch 12: Neurotransmitter and Cell Death”
Link: The University of Texas’s Neuroscience Online: Dr. Pramod Dash’s “Ch 12: Neurotransmitter and Cell Death” (HTML and Adobe Flash)
Instructions: Read the sections titled “Proteolytic Mechanisms of Cell Death” and “Secondary Injury.” Apoptosis is cell suicide, where as necrosis is unintentional cell death. Necrosis activates major inflammatory pathways and results in a host of other problems that apoptosis does not incur. Be sure to understand how and why one occurs and not the other.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Reading: The University of Texas’s Neuroscience Online: Dr. Pramod Dash’s “Ch 12: Neurotransmitter and Cell Death”
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4.3.2 Anterograde Degeneration
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 1: The Organization of the Nervous System – Recovery from Neural Injury”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 1: The Organization of the Nervous System – Recovery from Neural Injury” (HTML)
Instructions: Read the entire webpage, click on the embedded hyperlinks, and explore all figures. This reading also covers section 4.4.1 and 4.5.2.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The Saylor Foundation’s “Wallerian Degeneration”
Link: The Saylor Foundation’s “Wallerian Degeneration” (PDF)
Instructions: Download the reading linked above. Make sure to pay close attention to the figure provided.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 1: The Organization of the Nervous System – Recovery from Neural Injury”
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4.3.3 Retrograde Degeneration
- Reading: The Saylor Foundation’s “Retrograde Degeneration”
Link: The Saylor Foundation’s “Retrograde Degeneration” (PDF)
Instructions: Download the reading linked above. Make sure to pay close attention to the figure providedSee a broken link? Please let us know!
- Reading: The Saylor Foundation’s “Retrograde Degeneration”
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4.3.4 Transneuronal Degeneration
- Reading: The University of Texas’s Neuroscience Online: Dr. Andrew Bean’s “Ch 9: “Synapse Formation, Survival, and Elimination”
Link: The University of Texas’s Neuroscience Online: Dr. Andrew Bean’s “Ch 9: Synapse Formation, Survival, and Elimination” (HTML and Adobe Flash)
Instructions: Read the section titled “Neurons of the CNS Have Very Limited Capacity to Regenerate.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Andrew Bean’s “Ch 9: “Synapse Formation, Survival, and Elimination”
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4.3.5 Excitotoxicity
- Reading: Psychiatrist.com: Dr. Stephen M. Stahl’s “Excitotoxicity and Neuroprotection”
Link: Psychiatrist.com: Dr. Stephen M. Stahl’s “Excitotoxicity and Neuroprotection” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Psychiatrist.com: Dr. Stephen M. Stahl’s “Excitotoxicity and Neuroprotection”
- 4.4 Brain Repair
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4.4.1 CNS Damage Repair
Note: This topic is covered in the reading under subunit 4.3.2.
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4.4.2 Stem Cell Replacement
- Reading: NCBI Bookshelf: NeuroRX: Olle Lindvall and Anders Bjorklund’s (guest editors) Cell Replacement Therapy – “Helping the Brain to Repair Itself”
Link: NCBI Bookshelf: NeuroRX: Olle Lindvall and Anders Bjorklund’s (guest editors) Cell Replacement Therapy – “Helping the Brain to Repair Itself” (HTML)
Instructions: Read the entire webpage for an overview of cell replacement therapy in relation to the human brain.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf: NeuroRX: Olle Lindvall and Anders Bjorklund’s (guest editors) Cell Replacement Therapy – “Helping the Brain to Repair Itself”
- 4.5 PNS Repair
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4.5.1 Peripheral Nerve Regeneration
- Reading: The University of Texas’s Neuroscience Online: Professor Andrew Bean’s “Ch 9: Synapse Formation, Survival, and Elimination”
Link: The University of Texas’s Neuroscience Online: Professor Andrew Bean’s “Ch 9: Synapse Formation, Survival, and Elimination” (HTML and Adobe Flash)
Instructions: Read the section titled “Neurons in the Peripheral Nervous System Can Regenerate Their Axons.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Professor Andrew Bean’s “Ch 9: Synapse Formation, Survival, and Elimination”
-
4.5.2 Regeneration of Peripheral Synapses
- Reading: The University of Texas’s Neuroscience Online: Professor Andrew Bean’s “Ch 9: “Synapse Formation, Survival, and Elimination”
Link: The University of Texas’s Neuroscience Online: Professor Andrew Bean’s “Ch 9: Synapse Formation, Survival, and Elimination” (HTML and Adobe Flash)
Instructions: Read the section on “Neuronal Regeneration.” This also covers section 4.5.3.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Professor Andrew Bean’s “Ch 9: “Synapse Formation, Survival, and Elimination”
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4.5.3 Schwann Cells and Macrophage Repair

Note: This topic is covered by the reading under subunit 4.5.2.
- Assessment: The Saylor Foundation’s “Unit 4 Assessment”
Link: The Saylor Foundation's “Unit 4 Assessment” (PDF)
Instructions: Complete this quiz after working through Unit 3. The questions are either multiple choice, matching, or labeling diagrams. Your answers can be checked against The Saylor Foundation's “Unit 4 Assessment Answer Key” (PDF). This assessment will take roughly 30 minutes to complete.See a broken link? Please let us know!
- Assessment: The Saylor Foundation’s “Unit 4 Assessment”
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Unit 5: Neural Development
The nervous system, elaborate and complicated as it is, developed from a single cell. This unit will cover the major concepts behind the remarkable process of neural development. This unit’s information draws heavily from the developmental biology course; if you are interested in development, you should consider enrolling in that course as well.
Unit 5 Time Advisory show close
You will learn that the growth process begins with neurulation and neural tube formation and continues along a very fast path. It involves a huge number of different types of cells and signals but we will cover only those that have the most significant impact. Finally, we will examine some birth defects that arise from improper development.
Unit 5 Learning Outcomes show close
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5.1 Gastrulation and Neurulation
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5.1.1 Notochord
- Reading: Kenyon College: Life – The Science of Biology 6th Ed.: “Chapter 14: Gastrulation and Neurulation”
Link: Kenyon College: Life – The Science of Biology 6th Ed.: “Chapter 14: Gastrulation and Neurulation” (HTML and Quicktime)
Instructions: Read the sections on “Gastrulation,” “Gastrulation in Birds and Mammals,” and “Neurulation.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Kenyon College: Life – The Science of Biology 6th Ed.: “Chapter 14: Gastrulation and Neurulation”
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5.1.2 Primitive Streak and Pit
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 22: The Initial Formation of the Nervous System: Gastrulation and Neurulation”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 22: The Initial Formation of the Nervous System: Gastrulation and Neurulation” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 22: The Initial Formation of the Nervous System: Gastrulation and Neurulation”
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5.1.3 Retinoic Acid
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Box A – Retinoic Acid: Teratogen and Induction Signal”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Box A – Retinoic Acid: Teratogen and Induction Signal” (HTML)
Instructions: Read the entire webpage, and carefully view the images. Vitamin A is essential for the normal development of vertebrate embryos. If a developing embryo is deprived of vitamin A, the fetus, particularly the fetal brain, will not form correctly. Vitamin A itself is not directly responsible for the regulation of embryonic development. Vitamin A is metabolized to form RETINOIC ACID. Retinoic acid is essential in determining position along the embryonic anterior/posterior axis and the dorsal/ventral axis. The biological importance of retinoic acid has long been known, as major developmental abnormalities follow retinoic acid deprivation or exposure to excess retinoic acid. Some of these abnormalities resemble congenital birth defects that are relatively common in humans, including spina bifida and cleft palate.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Box A – Retinoic Acid: Teratogen and Induction Signal”
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5.1.4 Growth Factors, Bone Morphogenetic Proteins (BMPs), and Sonic Hedgehog (Shh)
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 22: The Molecular Basis of Neural Induction”
Link: NCBI Bookshelf’sversion of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 22: The Molecular Basis of Neural Induction” (HTML)
Instructions: Read the entire webpage. Note that you have already reviewed Box A in the previous subunit 5.1.3. You may want to spend some time re-reviewing this figure. Make sure to also click on the link to and explore Figure 22.3.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 22: The Molecular Basis of Neural Induction”
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5.2 Major Subdivision
- 5.3 Major Subdivision
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5.3.1 Prosencephalon
- Reading: The University of Texas’s Neuroscience Online: Dr. Dafny’s “Ch 1: Overview of the Nervous System”
Link: The University of Texas’s Neuroscience Online: Dr. Dafny’s “Ch 1: Overview of the Nervous System” (HTML)
Instructions: Read Chapter 1. This reading also covers subunits 5.2.2 and 5.2.3.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Dafny’s “Ch 1: Overview of the Nervous System”
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5.3.2 Mesencephalon
Note: This topic is covered by the reading under subunit 5.2.1.
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5.3.3 Rhombencephalon
Note: This topic is covered by the reading under subunit 5.2.1.
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5.3.4 Spinal Cord
- Reading: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 3: Anatomy of the Spinal Cord”
Link: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 3: Anatomy of the Spinal Cord” (HTML)
Instructions: Read all 4 pages of the chapter.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Temple University’s Neuroanatomy Lab Resource Appendices: “Neuroembryology”
Link: Temple University’s Neuroanatomy Lab Resource Appendices: “Neuroembryology” (HTML)
Instructions: Read both pages of this link. Make sure to click on the hyperlink labeled “Click here to move on to the next page” to move on to the second page of the article.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 3: Anatomy of the Spinal Cord”
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5.3.5 Homeotic Genes
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Box B – Homeotic Genes and Human Brain Development”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Box B – Homeotic Genes and Human Brain Development” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Box B – Homeotic Genes and Human Brain Development”
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5.3.6 Rhombomeres
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Box C – Rhombomeres”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Box C – Rhombomeres” (HTML)
Instructions: Read the entire webpage, and view the images carefully.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Box C – Rhombomeres”
- 5.4 Neuronal Differentiation
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5.4.1 Neurogenesis
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 22: The Initial Differentiation of Neurons and Glia”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 22: The Initial Differentiation of Neurons and Glia” (HTML)
Instructions: Read the entire webpage, and click on the hyperlinks to read Box D, Figure 22.6, and Figure 22.7.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 22: The Initial Differentiation of Neurons and Glia”
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5.4.2 Neural Crest Cells
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 22: The Initial Formation of the Nervous System: Gastrulation and Neurulation”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 22: The Initial Formation of the Nervous System: Gastrulation and Neurulation” (HTML)
Instructions: You have read this website in Subunit 5.1.2, but to focus on neural crest cells, please read the third paragraph, and click on the hyperlink to Figure 22.2.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 22: The Initial Formation of the Nervous System: Gastrulation and Neurulation”
- 5.5 Neural Circuit Formation
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5.5.1 Axonal Growth Cone
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 23: The Axonal Growth Cone”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 23: The Axonal Growth Cone” (HTML)
Instructions: Read the entire webpage, and click on the hyperlinks to the figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 23: The Axonal Growth Cone”
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5.5.2 Chemoattraction and Repulsion
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 23: Diffusible Signals for Axon Guidance: Chemoattraction and Repulsion”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 23: Diffusible Signals for Axon Guidance: Chemoattraction and Repulsion” (HTML)
Instructions: Read the entire webpage, and click on the hyperlinks to the figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 23: Diffusible Signals for Axon Guidance: Chemoattraction and Repulsion”
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5.5.3 Topographic Maps and Chemoaffinity Hypothesis
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 23: The Formation of Topographic Maps”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 23: The Formation of Topographic Maps” (HTML)
Instructions: Read the entire webpage, and click on the hyperlinks to the figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 23: The Formation of Topographic Maps”
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5.5.4 Neurotrophic Factors
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 23: Trophic Interactions and the Ultimate Size of Neuronal Populations”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 23: Trophic Interactions and the Ultimate Size of Neuronal Populations” (HTML)
Instructions: Read the entire webpage, and click on the hyperlinks to the figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 23: Trophic Interactions and the Ultimate Size of Neuronal Populations”
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5.5.5 Selective Synapse Formation
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 23: Selective Synapse Formation”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 23: Selective Synapse Formation” (HTML)
Instructions: Read the entire webpage, and click on the hyperlinks to the figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 23: Selective Synapse Formation”
- 5.6 Altered Development
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5.6.1 Fragile-X Syndrome
- Reading: The National Fragile-X Foundation: “Fragile X-associated Disorders”
Link: The National Fragile-X Foundation: “Fragile X-associated Disorders” (HTML)
Instructions: Read the entire webpage and click on the links to Fragile X syndrome, and Fragile X-associated Tremor/Ataxia Syndrome. Note that you are not required to fill out any information for the free brochure.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The National Fragile-X Foundation: “Fragile X-associated Disorders”
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5.6.2 Hydrocephalus
- Reading: National Institute of Neurological Disorder and Stroke: “Hydrocephalus Fact Sheet”
Link: National Institute of Neurological Disorder and Stroke: “Hydrocephalus Fact Sheet” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: National Institute of Neurological Disorder and Stroke: “Hydrocephalus Fact Sheet”
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5.6.3 Autism
- Reading: National Institute of Neurological Disorder and Stroke: “Autism Fact Sheet”
Link: National Institute of Neurological Disorder and Stroke: “Autism Fact Sheet” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: National Institute of Neurological Disorder and Stroke: “Autism Fact Sheet”
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5.6.4 Trisomy 21 (Down Syndrome)
- Reading: National Association for Down Syndrome: “Facts About Down Syndrome”
Link: National Association for Down Syndrome: “Facts About Down Syndrome” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Assessment: The Saylor Foundation’s “Unit 5 Assessment”
Link: The Saylor Foundation’s “Unit 5 Assessment” (PDF)
Instructions: Complete this quiz after working through Unit 5. The questions are either multiple choice, matching, or labeling diagrams. Your answers can be checked against The Saylor Foundation’s “Unit 5 Assessment Answer Key” (PDF).
Completing this assessment should take approximately 30 minutes.See a broken link? Please let us know!
- Reading: National Association for Down Syndrome: “Facts About Down Syndrome”
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Unit 6: Neuroanatomy
During development, various levels of organization are built into cells in order to create structure and order. This unit will introduce the most important structures in neurobiology, from the cerebral cortex to the base of the spinal cord. Neuroanatomy can be broken down into the “cephalons” (i.e. the top of the head is the telecephalon). As many of these structures are functionally unique but visually similar, it can be difficult to distinguish one from another. Thus, while you are learning these structures, it is important to reference a visual aid that will show you the location and shape.
Unit 6 Time Advisory show close
Unit 6 Learning Outcomes show close
- 6.1 Telencephalon
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6.1.1 Cerebral Cortex
- Reading: Center for Neuro Skills: Dr. Robert Lehr’s “Brain Functions and Map”
Link: Center for Neuro Skills: Dr. Robert Lehr’s “Brain Functions and Map” (HTML)
Instructions: Read the entire webpage, and click on the embedded links.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Center for Neuro Skills: Dr. Robert Lehr’s “Brain Functions and Map”
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6.1.2 The Cerebral Hemispheres
- Reading: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 1: Overview of the Nervous System”
Link: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 1: Overview of the Nervous System” (HTML)
Instructions: Read the first paragraph titled “The Cerebral Hemisphere.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 1: Overview of the Nervous System”
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6.1.3 Limbic System Structures
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 29: The Limbic System”
Link: NCBI Bookshelf’sversion of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 29: The Limbic System” (HTML)
Instructions: Read the entire page and explore the hyperlinks to the figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Web Media: YouTube: AndreeaOliviana’s “Limbic System and Prefrontal Cortex”
Link: YouTube: AndreeaOliviana’s “Limbic System and Prefrontal Cortex” (YouTube)
Instructions: Watch the video linked above (about 4 minutes). The limbic system includes many structures outside of the telecephalon.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 29: The Limbic System”
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6.1.4 Basal Ganglia
- Reading: Research Institute Neurosciences Vrije Universiteit: Henk J. Groenewegen’s “The Basal Ganglia and Motor Control”
Link: Vrije Universiteit, Neurosciences Research Institute: Henk J. Groenewegen’s “The Basal Ganglia and Motor Control” (PDF)
Instructions: Read this review on the basal ganglia to understand the anatomy and function of the basal ganglia.Reading this review should take approximately 3 hours.
Terms of Use: This resource is licensed under a Creative Commons Attribution 3.0 Unported License. It is attributed to Henk J. Groenewegen, and the original version can be found here.See a broken link? Please let us know!
- Reading: Research Institute Neurosciences Vrije Universiteit: Henk J. Groenewegen’s “The Basal Ganglia and Motor Control”
- 6.2 Diencephalon
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6.2.1 Thalamus, Hypothalamus, Prethalamus, and Epithalamus
- Reading: About.com’s Biology: Regina Bailey’s “Diencephalon”
Link: About.com’s Biology: Regina Bailey’s “Diencephalon” (HTML)
Instructions: Read the entire page, and click on the links for “thalamus,” “hypothalamus,” “pineal gland,” and “pituitary gland.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Web Media: YouTube: medbenmedben’s “Anatomy of the Brain: Diencephalon, Thalamus, and Hypothalamus”
Link: YouTube: medbenmedben’s “Anatomy of the Brain: Diencephalon, Thalamus, and Hypothalamus” (YouTube)
Instructions: Watch the video.
Watching this video should take approximately 5 minutes.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The Saylor Foundation’s “Thalamus, Hypothalamus, Prethalamus, and Epithalamus”
Link: The Saylor Foundation’s “Thalamus, Hypothalamus, Prethalamus, and Epithalamus” (PDF)
Instructions: Download the PDF linked above, and read the entire text.See a broken link? Please let us know!
- Reading: About.com’s Biology: Regina Bailey’s “Diencephalon”
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6.2.2 Pretectum
- Reading: NCBI Bookshelf’ s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 12: Central Projections of Retinal Ganglion Cells”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 12: Central Projections of Retinal Ganglion Cells” (HTML)
Instructions: Scroll down and read the fourth paragraph. Then, click the hyperlink to Figure 12.3. The pretectum (or pretectal area) is a region of neurons found between the thalamus and midbrain. The pretectum primarily controls the pupillary light reflex. The pupillary light reflex is controls the diameter of the pupil in response to the intensity of light that falls on the retina of the eye. The pupillary light reflex is important in adaptation to various levels of darkness and light. More intense light causes the pupil to become smaller (allowing less light in), and less intense light causes the pupil to become larger (allowing more light in). Thus, the pupillary light reflex regulates the intensity of light entering the eye.
The pretectum receives sensory information from the retinal ganglion cells in both eyes. After receiving information, it projects to the Edinger-Westphal nucleus and the ciliary ganglion, which regulate the size of the pupil by controlling the pupillary sphincter muscle and the pupillary dilator muscle, respectively.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’ s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 12: Central Projections of Retinal Ganglion Cells”
- 6.3 Mesencephalon
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6.3.1 Inferior and Superior Colliculi
- Reading: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 1: Overview of the Nervous System”
Link: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 1: Overview of the Nervous System” (HTML)
Instructions: Read the paragraphs on “Mesencephalon.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The Saylor Foundation’s “Inferior and Superior Colliculi”
Link: The Saylor Foundation’s “Inferior and Superior Colliculi” (PDF)
Instructions: Download the PDF linked above, and read the entire text.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 1: Overview of the Nervous System”
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6.3.2 Cerebral Peduncles
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 2: Spinal Reflexes and Descending Motor Pathways”
Link: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 2: Spinal Reflexes and Descending Motor Pathways” (HTML)
Instructions: Scroll to the section entitled: “2.2 Descending Motor Pathways” and read as far as “Rubrospinal tract.” You can stop there.
The cerebral peduncles are three sets of paired bundles of the hindbrain (superior, middle, and inferior), which carry body movement information from the cerebrum to the brainstem and spinal cord. By definition, a “peduncle” is a stem- or stalk-like structure of nerve tracts that connect various regions of the brain.
The cerebral peduncles can be divided into anterior section, the crus cerebri,and a posterior section, the tegmentum. The crus cerebri and tegmentumare separated by the substantia nigra.
The corticospinal tract runs through the cerebral peduncles. The corticospinal tract is a collection of axons that travel between the cerebral cortex and the spinal cord, which is involved with discrete voluntary skilled movements, particularly in the hands and fingers. For example, when the cerebrum instructs your hand to reach behind your back to grab a long stick, your corticospinal tract refines that instruction to have you twist your hand to the position of the stick which is easier to grab. The corticobulbar tract also runs through the cerebral peduncles. The corticobulbar tract connects the cerebral cortex and the brain stem and consists of motor neurons of some cranial nerves. Therefore, the corticobulbar tract controls muscles of the face, head, and neck.
Terms of use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 2: Spinal Reflexes and Descending Motor Pathways”
- 6.4 Metencephalon
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6.4.1 Pons
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 5: Cerebellum”
Link: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 5: Cerebellum” (HTML and Adobe Flash)
Instructions: Read the paragraph on the “Pons.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 5: Cerebellum”
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6.4.2 Cerebellum
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 5: Cerebellum”
Link: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 5: Cerebellum” (HTML and Adobe Flash)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 5: Cerebellum”
- 6.5 Myelencephalon
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6.5.1 Medulla Oblongata
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 5: Cerebellum”
Link: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 5: Cerebellum” (HTML and Adobe Flash)
Instructions: Read the paragraph on the “Medulla Oblongata.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 5: Cerebellum”
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6.5.2 Cranial Nerves
- Reading: NCBI Bookshelf’ s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Table 1.1: The Cranial Nerves and Their Primary Function”
Link: NCBI Bookshelf’ s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Table 1.1: The Cranial Nerves and Their Primary Function” (HTML)
Instructions: Read the entire table for a summary of cranial nerves and major functions.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Yale University School of Medicine: “Cranial Nerves”
Link: Yale University School of Medicine: “Cranial Nerves” (HTML)
Instructions: Click on each of the 12 types of cranial nerves to read about them. There are 12 cranial nerves (each having a specific function) as well as individual branches of larger cranial nerves. You should know them all!
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’ s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Table 1.1: The Cranial Nerves and Their Primary Function”
- 6.6 Spinal Cord
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6.6.1 Cervical, Thoracic, Lumbar, and Sacral Nerves
- Reading: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 3: Anatomy of the Spinal Cord”
Link: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 3: Anatomy of the Spinal Cord” (HTML)
Instructions: Read the entirety of this webpage, except for the paragraph on the “dermatome.” This reading also covers section 6.6.2.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 3: Anatomy of the Spinal Cord”
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6.6.2 Vertebral Column
Note: This topic is covered by the reading under subunit 6.6.1.
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6.6.3 Dorsal and Ventral Roots
- Reading: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 3: Anatomy of the Spinal Cord”
Link: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 3: Anatomy of the Spinal Cord” (HTML)
Instructions: Click “next” to page 3, and read the paragraph for the “Dorsal Root.” Then, click “next” to page 4, and read the paragraph for the “Ventral Root.” Dorsal roots are for sensory functions while ventral roots are for motor functions. Try not to mix these two up!
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 3: Anatomy of the Spinal Cord”
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6.6.4 Conus Medullaris and Cauda Equina
- Reading: Apparelyzed.com: “Spinal Cord Anatomy”
Link: Apparelyzed.com: “Spinal Cord Anatomy” (HTML)
Instructions: Read the webpage linked above.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Apparelyzed.com: “Spinal Cord Anatomy”
- 6.7 Ventricular System
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6.7.1 Cerebrospinal Fluid and Choroid Plexus
- Reading: NeuropathologyWeb.org: “Ch14 – Cerebrospinal Fluid”
Link: NeuropathologyWeb.org: “Ch14 – Cerebrospinal Fluid” (HTML)
Instructions: Read the webpage linked above.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NeuropathologyWeb.org: “Ch14 – Cerebrospinal Fluid”
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6.7.2 Lateral Ventricles
- Reading: Psyweb.com: “Ventricles”
Link: Psyweb.com: “Ventricles” (HTML)
Instructions: Read the webpage linked above.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Psyweb.com: “Ventricles”
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6.7.3 Third Ventricle
- Web Media: YouTube: Dr. Droual’s “Brain Stem Model – Lateral and Third Ventricles”
Link: YouTube: Dr. Droual’s “Brain Stem Model – Lateral and Third Ventricles” (YouTube)
Instructions: Watch the video, which should take you approximately 1 hour and 30 minutes.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Web Media: YouTube: Dr. Droual’s “Brain Stem Model – Lateral and Third Ventricles”
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6.7.4 Fourth Ventricle
- Web Media: YouTube: “Neuroanatomy – Ventricles”
Link: YouTube: “Neuroanatomy – Ventricles” (YouTube)
Instructions: Watch the video.
Watching this video should take approximately 5 minutes.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Web Media: YouTube: “Neuroanatomy – Ventricles”
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6.7.5 Summary of Ventricular System
- Reading: Academic.ru: “Ventricular System”
Link: Academic.ru: “Ventricular System” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Assessment: The Saylor Foundation’s “Unit 6 Assessment”
Link: The Saylor Foundation’s “Unit 6 Assessment” (PDF)
Instructions: Complete this quiz after working through Unit 6. The questions are either multiple choice, matching, or labeling diagrams. Your answers can be checked against The Saylor Foundation’s “Unit 6 Assessment Answer Key” (PDF).
Completing this assessment should take approximately 30 minutes.See a broken link? Please let us know!
- Reading: Academic.ru: “Ventricular System”
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Unit 7: Somatic Sensory System
We will now begin looking at global neural systems. We will begin with the somatic sensory system, which detects physical stimuli such as pressure, temperature, and pain. There are two subsystems within the larger somatic sensory system—one for pressure (mechanosensory) and the other for temperature (thermoception) and pain (nociception). Between these systems, we have a number of receptors that will inform us everything from temperature to muscle stretch. We know a great deal about how these systems work. For example, our use of menthol and capsaicin takes advantage of temperature sensation to enable the feeling of “cool” mints and “spicy” oils. Our somatic sensory is among the oldest and most primitive of nervous functions, existing even in the simplest of organisms.
Unit 7 Time Advisory show close
Unit 7 Learning Outcomes show close
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7.1 Sensory Receptors
- Reading: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems”
Link: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems” (HTML and Adobe Flash)
Instructions: Read the first paragraph on “Cutaneous Receptors,” and then take the quiz included at the end of this webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems”
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7.1.1 Free Nerve Endings
- Reading: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems”
Link: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems” (HTML and Adobe Flash)
Instructions: On the webpage linked above, scroll down and read the section on “Free Nerve Endings.” Then click the “next” link to page 5 and read “Free Nerve Endings.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems”
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7.1.2 Meissner’s and Pacinian Corpuscles
- Reading: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems”
Link: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems” (HTML and Adobe Flash)
Instructions: Read the sections “Cutaneous Receptors,” “Meissner Corpuscles,” and “Pacinian Corpuscles.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems”
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7.1.3 Merkel’s Disks
- Reading: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems”
Link: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems” (HTML and Adobe Flash)
Instructions: Scroll down and read sections titled “Hair follicle” and “Merkel Complex.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems”
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7.1.4 Ruffini’s Corpuscles
- Reading: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems”
Link: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems” (HTML and Adobe Flash)
Instructions: Scroll down and read the section titled “Ruffini Corpuscles.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems”
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7.1.5 Muscle Spindles
- Reading: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems”
Link: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems” (HTML and Adobe Flash)
Instructions: Read the section titled “Muscle Spindles.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems”
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7.1.6 Golgi Tendon Organs (GTO)
- Reading: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems”
Link: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems” (HTML and Adobe Flash)
Instructions: Scroll down and read the section titled “Golgi Tendon Organs.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems”
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7.1.7 Joint Receptors
- Reading: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems”
Link: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems” (HTML and Adobe Flash)
Instructions: Scroll down and read the section titled “Joint Receptors.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 2: Somatosensory Systems”
- 7.2 Mechanosensory Pathway
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7.2.1 Threshold and Two-Point Discrimination
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 9: Differences in Mechanosensory Discrimination Across the Body Surface”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 9: Differences in Mechanosensory Discrimination Across the Body Surface” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 9: Differences in Mechanosensory Discrimination Across the Body Surface”
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7.2.2 Proprioception
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 9: Mechanoreceptors Specialized for Proprioception”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 9: Mechanoreceptors Specialized for Proprioception” (HTML)
Instructions: Read the entire webpage. Proprioception is the ability to know where you are in space. To understand this concept, close your eyes and point to your nose with your right index finger. You managed to complete this task without looking at your hand through the “magic” of proprioception. There are several types of receptors that function together to provide your brain with proprioception information. You should be able to identify these types of receptors and the contributions that each makes.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 9: Mechanoreceptors Specialized for Proprioception”
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7.2.3 Dermatomes
- Reading: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 3: Anatomy of the Spinal Cord”
Link: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 3: Anatomy of the Spinal Cord” (HTML and Adobe Flash)
Instructions: Scroll down and read the paragraph beginning “A dermatome is an area of skin…” and the associated Figure 3.5.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 3: Anatomy of the Spinal Cord”
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7.2.4 Dorsal Column-Medial Lemniscus (DCML) Pathway
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 9: The Major Afferent Pathway for Mechanosensory Information: The Dorsal Column-Medial Lemniscus System”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 9: The Major Afferent Pathway for Mechanosensory Information: The Dorsal Column-Medial Lemniscus System” (HTML)
Instructions: Read the entire webpage, click on the embedded hyperlinks, and explore all figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 9: The Major Afferent Pathway for Mechanosensory Information: The Dorsal Column-Medial Lemniscus System”
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7.2.5 Trigeminothalamic Pathway
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 9: The Trigeminal Portion of the Mechanosensory System”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 9: The Trigeminal Portion of the Mechanosensory System” (HTML)
Instructions: Read the entire webpage, click on any embedded links, and explore all figures. Both the DCML and trigeminothalamic pathways provide physical stimuli information to the brain. One covers the face, while the other covers the rest of the body. Be sure to know which one is which, and be able to trace a typical pathway of each in the body!
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 9: The Trigeminal Portion of the Mechanosensory System”
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7.2.6 Somatic Sensory Cortices and Homunculus
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 9: The Somatic Sensory Cortex”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 9: The Somatic Sensory Cortex” (HTML)
Instructions: Read the entire webpage, click on any embedded links, and explore all figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 9: The Somatic Sensory Cortex”
- 7.3 Temperature and Pain
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7.3.1 Nociceptor Types
- Reading: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 6: Pain Principles”
Link: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 6: Pain Principles” (HTML and Adobe Flash)
Instructions: Read the introduction, section 6.1 “Pain receptors”, and section 6.6 “Nociceptor Neurons in the Spinal Cord (Nocineurons).”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 6: Pain Principles”
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7.3.2 Heat and Cold Perception
- Reading: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 4: Somatosensory Pathways”
Link: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 4: Somatosensory Pathways” (HTML and Adobe Flash)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 4: Somatosensory Pathways”
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7.3.3 First and Second Pain
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 10: The Perception of Pain”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 10: The Perception of Pain” (HTML)
Instructions: Read the entire webpage, click on any embedded links, and explore all figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 10: The Perception of Pain”
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7.3.4 Referred Pain
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Box A – Referred Pain”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Box A – Referred Pain” (HTML)
Instructions: Read the entire webpage, and view the figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Box A – Referred Pain”
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7.3.5 Anterolateral System
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 10: Central Pain Pathways: The Spinothalamic Tract”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 10: Central Pain Pathways: The Spinothalamic Tract” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 10: Central Pain Pathways: The Spinothalamic Tract”
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7.3.6 Trigeminal Tract
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 9: The Trigeminal Portion of the Mechanosensory System”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 9: The Trigeminal Portion of the Mechanosensory System” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 9: The Trigeminal Portion of the Mechanosensory System”
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7.3.7 Sensitization
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 10: Hyperalgesia and Sensitization”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 10: Hyperalgesia and Sensitization” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Assessment: The Saylor Foundation’s “Unit 7 Quiz”
Link: The Saylor Foundation’s “Unit 7 Quiz” (PDF)
Instructions: Complete the entire assessment. You can check your answers with The Saylor Foundation’s “Unit 7 Answer Key” (PDF).See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 10: Hyperalgesia and Sensitization”
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Unit 8: Special Senses
This unit will cover all of our special senses. While you may know the four common ones (sight, smell, taste, hearing), you may not be familiar with the vestibular sense, which helps us orient ourselves in terms of head position, motion, and spatial awareness. Each of these senses has its own unique anatomy as well as system of detecting stimuli, and each sense projects to different parts of the brain. Because we depend on these senses for everyday function, they have sophisticated and complex mechanisms of action.
Unit 8 Time Advisory show close
Unit 8 Learning Outcomes show close
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8.1 Vision
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8.1.1 Eye Anatomy
- Reading: Howard Hughes Medical Institute: Neuroscience Lecture Series – 1997 Holiday Lectures: “Senses and Sensitivity: Neuronal Alliances for Sight and Sound”
Link: Howard Hughes Medical Institute: Neuroscience Lecture Series – 1997 Holiday Lectures: “Senses and Sensitivity: Neuronal Alliances for Sight and Sound” (Adobe Flash or RealPlayer)
Instructions: Scroll down to the 1997 Holiday Lectures. Click on the link to Lecture 2: “The Science of Sight: Getting the Picture, by Jeremy Nathans, M.D., Ph.D,” then, on the right margin, click on “2. Contrasting the eye and how a camera works.” The video will begin at 5:45. Watch the video until Section 7, or until 41:06. This video will cover the topics outlined in sections 8.1.1, 8.1.2, and 8.1.3.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Howard Hughes Medical Institute: Neuroscience Lecture Series – 1997 Holiday Lectures: “Senses and Sensitivity: Neuronal Alliances for Sight and Sound”
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8.1.2 Image Formation and Accommodation
- Reading: Davidson College: Webphysics: “The Human Eye”
Link: Davidson College: Webphysics: “The Human Eye” (HTML and JAVA)
Instructions: Read the entire webpage. Follow the webpage’s instructions for visualization of the applet.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Davidson College: Webphysics: “The Human Eye”
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8.1.3 Rods and Cones
Note: This topic is covered by the resource under subunit 8.1.1.
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8.1.4 Phototransduction
- Reading: OpenWetWare: Bio254: “Phototransduction”
Link: OpenWetWare: Bio254: “Phototransduction” (HTML)
Instructions: Click on “3. Phototransduction step by step,” and read all of section 3.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: OpenWetWare: Bio254: “Phototransduction”
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8.1.5 On-center and Off-center Ganglia Cells
- Reading: University of Utah: Webvision’s “Outer Plexiform Layer”
Link: University of Utah: Webvision’s “Outer Plexiform Layer” (HTML)
Instructions: Scroll down the webpage to the section titled “ON and OFF pathways of the retina are initiated at the photoreceptor to bipolar contacts.” Read this entire section.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: University of Utah: Webvision’s “Outer Plexiform Layer”
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8.1.6 Optic Nerve, Optic Chiasm, and Visual Fields
- Reading: Dr. Ted M. Montgomery’s “Anatomy, Physiology & Pathology of the Human Eye - The Optic Nerve”
Link: Dr. Ted M. Montgomery’s “Anatomy, Physiology & Pathology of the Human Eye - The Optic Nerve” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Dr. Ted M. Montgomery’s “Anatomy, Physiology & Pathology of the Human Eye - The Optic Nerve”
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8.1.7 Cortical Visual Pathway
- Reading: The University of Texas’s Neuroscience Online: Dr. Valentin Dragoi’s “Ch 15: Visual Processing: Cortical Pathways”
Link: The University of Texas’s Neuroscience Online: Dr. Valentin Dragoi’s “Ch 15: Visual Processing: Coritical Pathways” (HTML)
Instructions: Read the entire section titled “The Visual Pathway from Retina to Cortex,” focusing on the subsections “The Optic Nerve” and “The Lateral Geniculate Nucleus.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Valentin Dragoi’s “Ch 15: Visual Processing: Cortical Pathways”
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8.1.8 Visual Cortices
- Reading: The University of Texas’s Neuroscience Online: Dr. Valentin Dragoi’s “Ch 15: Visual Processing: Cortical Pathways”
Link: The University of Texas’s Neuroscience Online: Dr. Valentin Dragoi’s “Ch 15: Visual Processing: Coritical Pathways” (HTML)
Instructions: Scroll down the webpage, and read the section titled “Visual Cortical Areas.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Valentin Dragoi’s “Ch 15: Visual Processing: Cortical Pathways”
- 8.2 Auditory
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8.2.1 Audible Spectrum
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 13: The Audible Spectrum”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 13: The Audible Spectrum” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 13: The Audible Spectrum”
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8.2.2 Outer, Middle, Inner Ears
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: Ch 13: The Auditory System: “The Middle Ear,” “The Inner Ear,” and “The External Ear”
Links: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: Ch 13: The Auditory System: “The Middle Ear,” (HTML) “The Inner Ear,” (HTML) and “The External Ear” (HTML)
Instructions: Read the entire content of the webpages as well as the hyperlinks to the figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: Ch 13: The Auditory System: “The Middle Ear,” “The Inner Ear,” and “The External Ear”
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8.2.3 Inner and Outer Hair Cells
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 13: Two Kinds of Hair Cells in the Cochlea”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch13: Two Kinds of Hair Cells in the Cochlea” (HTML)
Instructions: Read the entire webpage, click on any embedded hyperlinks, and explore all figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 13: Two Kinds of Hair Cells in the Cochlea”
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8.2.4 Mechanoelectrical Transduction
- Web Media: 1Lecture.com: “Effect of Sound Waves on Cochlear Structures”
Link: 1Lecture.com: “Effect of Sound Waves on Cochlear Structures” (Adobe Flash)
Instructions: Watch the video.
Watching this video should take approximately 5 minutes.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Web Media: 1Lecture.com: “Effect of Sound Waves on Cochlear Structures”
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8.2.5 Integration of Information from Two Ears
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 13: Integrating Information from the Two Ears”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 13: Integrating Information from the Two Ears” (HTML)
Instructions: Read the entire webpage, click on any hyperlinks to figures, and read any accompanying text for each figure. The auditory system has a unique and intriguing way of figuring out the directional origin of sound; it uses selective signaling pathways. Be sure to understand how the system this works.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.
See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 13: Integrating Information from the Two Ears”
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8.2.6 Inferior Colliculus and Auditory Space Map
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition “Ch 13: Integration in the Inferior Colliculus”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 13: Integration in the Inferior Colliculus” (HTML)
Instructions: Read the entire webpage, click on all hyperlinks to figures, and read the accompanying text for each figure.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition “Ch 13: Integration in the Inferior Colliculus”
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8.2.7 Auditory Thalamus and Auditory Cortex
- Reading: The University of Texas’s Neuroscience Online: Dr. Lincoln Gray’s “Ch 13: Auditory System: Pathways and Reflexes”
Link: The University of Texas’s Neuroscience Online: Dr. Lincoln Gray’s “Ch 13: Auditory System: Pathways and Reflexes” (HTML and Adobe Flash)
Instructions: Read the entire webpage. Then, take the quiz at the end of the page.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Lincoln Gray’s “Ch 13: Auditory System: Pathways and Reflexes”
- 8.3 Vestibular System
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8.3.1 Otolith Organs
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 14: The Otolith Organs: The Utricle and Sacculus”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 14: The Otolith Organs: The Utricle and Sacculus” (HTML)
Instructions: Read the entire webpage, click on the links to any figures, and read the accompanying text for each figure.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 14: The Otolith Organs: The Utricle and Sacculus”
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8.3.2 Semicircular Canals
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 14: The Semicircular Canals”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 14: The Semicircular Canals” (HTML)
Instructions: Read the entire webpage, and click on and read the text for any embedded hyperlinks. This reading also covers section 8.3.3.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 14: The Semicircular Canals”
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8.3.3 Angular and Linear Accelerations
Note: This topic is covered by the reading under subunit 8.3.2.
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8.3.4 Scarpa’s Ganglion
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 14: Central Vestibular Pathways: Eye, Head, and Body Reflexes”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 14: Central Vestibular Pathways: Eye, Head, and Body Reflexes” (HTML)
Instructions: Read the entire webpage and explore all hyperlinks to figures. This reading also covers section 8.3.5.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 14: Central Vestibular Pathways: Eye, Head, and Body Reflexes”
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8.3.5 Vestibular Pathways
Note: This topic is covered by the reading beneath subunit 8.3.4.
- 8.4 Olfaction
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8.4.1 Olfactory System Anatomy
- Lecture: Howard Hughes Medical Institute: Neuroscience Lecture Series – 1997 Holiday Lectures: “Senses and Sensitivity: Neuronal Alliances for Sight and Sound”
Link: Howard Hughes Medical Institute: Neuroscience Lecture Series – 1997 Holiday Lectures: “Senses and Sensitivity: Neuronal Alliances for Sight and Sound” (Adobe Flash or RealPlayer)
Instructions: Scroll down to 1997 Holiday Lectures. Click on the link to “Lecture 1 - Sensory Transduction: Getting the Message, by A. James Hudspeth, Ph.D., M.D.,”
Watch the video from 28:00 to 31:00.
Watching this video should take approximately 5 minutes.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Lecture: Howard Hughes Medical Institute: Neuroscience Lecture Series – 1997 Holiday Lectures: “Senses and Sensitivity: Neuronal Alliances for Sight and Sound”
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8.4.2 Odorants, Threshold, and Adaptation
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: Olfactory Perception in Humans”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: Olfactory Perception in Humans” (HTML)
Instructions: Read the entire webpage and explore all hyperlinks to figures. For adaptation, see section 8.4.3.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: Olfactory Perception in Humans”
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8.4.3 Odorant Receptors and Olfactory Receptor Neurons
- Reading: The University of Texas’s Neuroscience Online: Dr. Max Hutchin’s “Ch 9: Chemical Senses: Olfaction and Gustation”
Link: The University of Texas’s Neuroscience Online: Dr. Max Hutchin’s “Ch 9: Chemical Senses: Olfaction and Gustation” (HTML)
Instructions: Read the introduction, and scroll down to the “Olfactory System” section.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Max Hutchin’s “Ch 9: Chemical Senses: Olfaction and Gustation”
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8.4.4 Signal Transduction of Olfactory Neurons
- Lecture: Howard Hughes Medical Institute: Neuroscience Lecture Series – 1997 Holiday Lectures: “Senses and Sensitivity: Neuronal Alliances for Sight and Sound”
Link: Howard Hughes Medical Institute: Neuroscience Lecture Series – 1997 Holiday Lectures: “Senses and Sensitivity: Neuronal Alliances for Sight and Sound” (Adobe Flash or RealPlayer)
Instructions: Scroll down to 1997 Holiday Lectures, then click on “Lecture 1 - Sensory Transduction: Getting the Message, by A. James Hudspeth, Ph.D., M.D.” Next, in the right margin, click on “6. Encoding the signal and transmission to the brain.”
Watch the video until the 39 minute mark.
Watching this video should take approximately 40 minutes.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Lecture: Howard Hughes Medical Institute: Neuroscience Lecture Series – 1997 Holiday Lectures: “Senses and Sensitivity: Neuronal Alliances for Sight and Sound”
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8.4.5 Central Projections of Olfactory Bulb
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: Central Projections of Olfactory Bulb”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: Central Projections of Olfactory Bulb” (HTML)
Instructions: Read the entire webpage; be sure to explore the text for any embedded hyperlinks.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: Central Projections of Olfactory Bulb”
- 8.5 Gustation
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8.5.1 Taste System Anatomy
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: The Organization of the Taste System”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: The Organization of the Taste System” (HTML)
Instructions: Read the entire webpage; be sure to explore the text for any embedded hyperlinks.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: The Organization of the Taste System”
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8.5.2 Five Perceived Tastes
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: Taste Perception in Humans”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: Taste Perception in Humans” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: Taste Perception in Humans”
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8.5.3 Taste Cells and Taste Buds
- Reading: The University of Texas’s Neuroscience Online: Dr. Max Hutchin’s “Ch 9: Chemical Senses: Olfaction and Gustation”
Link: The University of Texas’s Neuroscience Online: Dr. Max Hutchin’s “Ch 9: Chemical Senses: Olfaction and Gustation” (HTML)
Instructions: Read the introduction and the “Gustatory System” section.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Max Hutchin’s “Ch 9: Chemical Senses: Olfaction and Gustation”
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8.5.4 Distribution of Taste Buds
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “The Organization of the Taste System”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “The Organization of the Taste System” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “The Organization of the Taste System”
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8.5.5 Supertasters
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: Idiosyncratic Responses to Various Tastants”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: Idiosyncratic Responses to Various Tastants” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: Idiosyncratic Responses to Various Tastants”
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8.5.6 Transduction of Gustation Signals
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: Taste Receptors and the Transduction of Taste Signals”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: Taste Receptors and the Transduction of Taste Signals” (HTML)
Instructions: Read the entire webpage; be sure to explore the text for any embedded hyperlinks.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: Taste Receptors and the Transduction of Taste Signals”
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8.5.7 Neural Coding
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: Neural Coding in the Taste System”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: Neural Coding in the Taste System” (HTML)
Instructions: Read the entire webpage; be sure to explore the text for any embedded hyperlinks.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: Neural Coding in the Taste System”
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8.5.8 Solitary Tract and Solitary Nucleus
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: Central Processing of Taste Signals”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: Central Processing of Taste Signals” (HTML)
Instructions: Read the entire webpage; be sure to explore the text for any embedded hyperlinks.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Assessment: The Saylor Foundation’s “Unit 8 Quiz”
Link: The Saylor Foundation’s “Unit 8 Quiz” (PDF)
Instructions: Complete the entire assessment. You can check your answers with The Saylor Foundation’s “Unit 8 Answer Key” (PDF).See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 15: Central Processing of Taste Signals”
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Unit 9: Motor Systems
We will now focus on motor systems. Much of our motor control takes place through nerve-to-muscle signaling in the form of the neuromuscular junction. You will learn that fine motor control and movement modulation – though involuntary – require a great deal of nervous input and output. You will also learn about the autonomic nervous system, which controls many of our internal organs. This unit will encompass both aspects of voluntary and involuntary motor control, examining the systems and major mechanisms of movement.
Unit 9 Time Advisory show close
Unit 9 Learning Outcomes show close
- 9.1 Lower Motor Circuits
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9.1.1 Lower Motor Neurons and Motor Neurons
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Functional Organization of the Primary Motor Cortex” and “The Motor Unit”
Links: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Functional Organization of the Primary Motor Cortex” (HTML) and “The Motor Unit” (HTML)
Instructions: Click on the first link, and read the entire webpage for lower motor neurons. Then, click on the second link, and read the entire webpage to learn about α-motor Neurons.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Functional Organization of the Primary Motor Cortex” and “The Motor Unit”
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9.1.2 Local Circuit
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 17: Descending Control of Spinal Cord Circuitry: General Information”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 17: Descending Control of Spinal Cord Circuitry: General Information” (HTML)
Instructions: Read the webpage, and click on the hyperlinks to Figure 17.1.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 17: Descending Control of Spinal Cord Circuitry: General Information”
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9.1.3 Ventral Horn
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 17: Descending Control of Spinal Cord Circuitry: General Information”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 17: Descending Control of Spinal Cord Circuitry: General Information” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 17: Descending Control of Spinal Cord Circuitry: General Information”
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9.1.4 Neuromuscular Junction
- Reading: The University of Texas’s Neuroscience Online: Dr. John Byrne’s “Ch 4: Synaptic Transmission and the Skeletal Neuromuscular Junction”
Link: The University of Texas’s Neuroscience Online: Dr. John Byrne’s “Ch 4: Synaptic Transmission and the Skeletal Neuromuscular Junction” (HTML)
Instructions: Read the first two sections of the webpage “Anatomy of the Neuromuscular Junction” and “Physiology of Synaptic Transmission at the Neuromuscular Junction.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. John Byrne’s “Ch 4: Synaptic Transmission and the Skeletal Neuromuscular Junction”
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9.1.5 Somatotopic Organization
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 16: Motor Neuron-Muscle Relationships”
Link: NCBI Bookshelf’sversion of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 16: Motor Neuron-Muscle Relationships” (HTML)
Instructions: Read the entire webpage, click on any embedded hyperlinks, and focus on the figures and tables.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 16: Motor Neuron-Muscle Relationships”
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9.1.6 Motor Units
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 1: Motor Units and Muscle Receptors”
Link: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 1: Motor Units and Muscle Receptors” (HTML)
Instructions: Read the section on “Motor Neurons.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 1: Motor Units and Muscle Receptors”
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9.1.7 Size Principle
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 1: Motor Units and Muscle Receptors”
Link: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 1: Motor Units and Muscle Receptors” (HTML and Adobe Flash)
Instructions: Read the section on “Control of Muscle Force.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 1: Motor Units and Muscle Receptors”
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9.1.8 Stretch Reflex and Motor Neurons
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 2: Spinal Reflexes and Descending Motor Pathways”
Link: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 2: Spinal Reflexes and Descending Motor Pathways” (HTML and Adobe Flash)
Instructions: Read the entire chapter. This reading also covers section 9.1.9.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 2: Spinal Reflexes and Descending Motor Pathways”
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9.1.9 Extensor and Flexor Pairs
Note: This topic is covered by the reading under subunit 9.1.
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9.1.10 Golgi Tendon Organs
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 1: Motor Units and Muscle Receptors”
Link: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 1: Motor Units and Muscle Receptors” (HTML and Adobe Flash)
Instructions: Read the entire webpage. Complete the quiz at the bottom of the page.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 1: Motor Units and Muscle Receptors”
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9.1.11 Central Pattern Generators
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 16: Spinal Cord Circuitry and Locomotion”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 16:Spinal Cord Circuitry and Locomotion” (HTML)
Instructions: Read the entire webpage. Also, click on any embedded hyperlinks, focus on the figures and Box B, and read its contents.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 16: Spinal Cord Circuitry and Locomotion”
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9.1.12 Lower Motor Neuron Syndrome
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 6: Disorders of the Motor System”
Link: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 6: Disorders of the Motor System” (HTML)
Instructions: Read the section on the “Lower Motor Neuron Syndrome.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 6: Disorders of the Motor System”
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9.1.13 Amyotrophic Lateral Sclerosis
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Box C - Amyotrophic Lateral Sclerosis”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Box C - Amyotrophic Lateral Sclerosis” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Box C - Amyotrophic Lateral Sclerosis”
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9.2 Upper Motor Circuits
Note: Decussation refers to the crossing over of nerve fibers from the left side of the body to the right side and vice versa. Most tracts that are discussed in this subunit have some decussation but some do not. Be sure to know which ones do not!
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9.2.1 General Upper Motor Control Characteristics
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 17: The Primary Motor Cortex: Upper Motor Neurons That Initiate Complex Voluntary Movements”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 17: The Primary Motor Cortex: Upper Motor Neurons That Initiate Complex Voluntary Movements” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 17: The Primary Motor Cortex: Upper Motor Neurons That Initiate Complex Voluntary Movements”
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9.2.2 Colliculus and Colliculospinal Tract / Tectospinal Tract
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 2: Spinal Reflexes and Descending Motor Pathways”
Link: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 2: Spinal Reflexes and Descending Motor Pathways” (HTML and Adobe Flash)
Instructions: Scroll down and read the paragraph on “Tectospinal tract.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 2: Spinal Reflexes and Descending Motor Pathways”
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9.2.3 Red Nucleus and Rubrospinal Tract
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 2: Spinal Reflexes and Descending Motor Pathways”
Link: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 2: Spinal Reflexes and Descending Motor Pathways” (HTML and Adobe Flash)
Instructions: Scroll down and read the paragraph on the “Rubrospinal tract.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 2: Spinal Reflexes and Descending Motor Pathways”
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9.2.4 Reticular Formation and Reticulospinal Tract
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 2: Spinal Reflexes and Descending Motor Pathways”
Link: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 2: Spinal Reflexes and Descending Motor Pathways” (HTML and Adobe Flash)
Instructions: Scroll down and read paragraph on the “Reticulospinal tract.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 2: Spinal Reflexes and Descending Motor Pathways”
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9.2.5 Premotor and Motor Cortices
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 3: Motor Cortex”
Link: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 3: Motor Cortex” (HTML and Adobe Flash)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 3: Motor Cortex”
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9.2.6 Homonculus of Primary Motor Cortex
Note: This topic is covered by the reading assigned beneath subunit 9.2.5. Focus on the section beginning “Like the somatosensory cortex of the postcentral gyrus…” and Figure 3.3.
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9.2.7 Upper Motor Neuron Syndrome
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 6: Disorders of the Motor System”
Link: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 6: Disorders of the Motor System” (HTML and Adobe Flash)
Instructions: Scroll down and read the paragraph on “Upper Motor Neuron Syndrome.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 6: Disorders of the Motor System”
- 9.3 Movement Modulation
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9.3.1 Basal Ganglia and Cerebellum Components
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 4: Basal Ganglia”
Link: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 4: Basal Ganglia” (HTML)
Instructions: Read the entire webpage. This reading also covers sections 9.3.3 and 9.3.4.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. James Knierim’s “Ch 4: Basal Ganglia”
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9.3.2 Corticostriatal Tract
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 18: Projections to the Basal Ganglia”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 18:Projections to the Basal Ganglia” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 18: Projections to the Basal Ganglia”
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9.3.3 Globus Pallidus and Putamen
Note: This topic is covered by the reading beneath subunit 9.3.1.
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9.3.4 Projections from Basal Ganglia
Note: This topic is covered by the reading beneath subunit 9.3.1.
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9.3.5 Basal Ganglia Loops
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Box C - Basal Ganglia Loops and Non-Motor Brain Functions”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Box C - Basal Ganglia Loops and Non-Motor Brain Functions” (HTML)
Instructions: Read the entire webpage, and carefully review the figure.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Box C - Basal Ganglia Loops and Non-Motor Brain Functions”
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9.3.6 Spinocerebellar Tract
- Reading: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 3: Anatomy of the Spinal Cord”
Link: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 3: Anatomy of the Spinal Cord” (HTML)
Instructions: Read the webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 3: Anatomy of the Spinal Cord”
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9.3.7 Cortico-ponto-cerebellar Pathway
- Web Media: YouTube: Drawtoknowit’s “Corticopontocerebellar Pathway”
Link: YouTube: Drawtoknowit’s “Corticopontocerebellar Pathway” (HTML)
Instructions: Watch the brief, half-minute video.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.The Saylor Foundation does not yet have materials for this portion of the course. If you are interested in contributing your content to fill this gap or aware of a resource that could be used here, please submit it here.
- Web Media: YouTube: Drawtoknowit’s “Corticopontocerebellar Pathway”
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9.3.8 Cortical Projections to Cerebellum
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Projections to Cerebellum”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Projections to Cerebellum” (HTML)
Instructions: Read the entire webpage, and click on the embedded hyperlinks, particularly to explore all figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Projections to Cerebellum”
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9.3.9 Cerebellar Circuits
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Circuits within the Cerebellum”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Circuits within the Cerebellum” (HTML)
Instructions: Read the entire webpage, and click on the embedded hyperlinks, particularly to explore all figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Circuits within the Cerebellum”
- 9.4 Visceral Motor Control
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9.4.1 Unique Features of Visceral Control
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Central Control of the Visceral Motor Functions”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Central Control of the Visceral Motor Functions” (HTML)
Instructions: Read the entire webpage, and click on the embedded hyperlinks, particularly to explore all figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Central Control of the Visceral Motor Functions”
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9.4.2 Sympathetic Division
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 21: The Sympathetic Division of the Visceral Motor System”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 21: The Sympathetic Division of the Visceral Motor System” (HTML)
Instructions: Read the entire webpage, and click on the embedded hyperlinks, particularly to explore all figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 21: The Sympathetic Division of the Visceral Motor System”
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9.4.3 Parasympathetic Division
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 21: The Parasympathetic Division of the Visceral Motor System”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 21: The Parasympathetic Division of the Visceral Motor System” (HTML)
Instructions: Read the entire webpage, and click on the hyperlinks to all figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 21: The Parasympathetic Division of the Visceral Motor System”
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9.4.4 Enteric System
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 21: The Enteric System”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 21: The Enteric System” (HTML)
Instructions: Read the entire webpage, and click on the hyperlinks to all figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 21: The Enteric System”
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9.4.5 Solitary Tract and Autonomic Control
- Reading: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 3: Central Control of the Nervous System and Thermoregulation”
Link: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 3: Central Control of the Nervous System and Thermoregulation” (HTML and Adobe Flash)
Instructions: Read the section “Circuitry for Hypothalamic Control of the Autonomic Nervous System” and Figure 3.3.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 3: Central Control of the Nervous System and Thermoregulation”
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9.4.6 Central Autonomic Network
- Reading: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 3: Central Control of the Nervous System and Thermoregulation”
Link: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 3: Central Control of the Nervous System and Thermoregulation” (HTML and Adobe Flash)
Instructions: Read the paragraphs on “Defining the Central Autonomic Network” and the “Structure of the Central Autonomic Network.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Patrick Dougherty’s “Ch 3: Central Control of the Nervous System and Thermoregulation”
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9.4.7 ?- and ?-Adrenergic Receptors
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 7: Catecholamine Receptors”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch7: Catecholamine Receptors” (HTML)
Instructions: Read the entire webpage, and click on all hyperlinks to figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 7: Catecholamine Receptors”
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9.4.8 Cholinergic Receptors
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 7: Cholinergic Receptors”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 7: Cholinergic Receptors” (HTML)
Instructions: Read the entire webpage, and click on all hyperlinks to figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Assessment: The Saylor Foundation’s “Unit 9 Assessment”
Link: The Saylor Foundation’s “Unit 9 Assessment” (PDF)
Instructions: Complete this quiz after working through Unit 9. The questions are either multiple choice, matching, or labeling diagrams. You can check your answers with the Saylor Foundation’s “Unit 9 Answer Key” (PDF).See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 7: Cholinergic Receptors”
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Unit 10: Cortical Brain Functions
The ability to talk, learn, and show emotion are among the most fundamental and intriguing functions of the human brain. This unit will provide an overview of these essential functions, known as “cortical brain functions” despite the fact that are quite complex and involve more than just the brain.
Unit 10 Time Advisory show close
Much of our information about cortical brain function has been derived from examining the symptoms and profiles of patients with damage to specific regions of the brain. Recently, the development of noninvasive procedures has enabled us to examine subjects to further understand neurological mechanisms and thus led to the establishment of a sub-neuroscience field known as cognitive neuroscience. Researchers in this subfield strive to elucidate the molecular and physiological basis for these functions.
Unit 10 Learning Outcomes show close
- 10.1 Cortex Overview
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10.1.1 White Matter and Grey Matter
- Reading: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 1: Overview of the Nervous System”
Link: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 1: Overview of the Nervous System” (HTML)
Instructions: Read the first paragraph on the linked page above.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 1: Overview of the Nervous System”
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10.1.2 Cell Types
- Reading: The University of Texas’s Neuroscience Online: Dr. Jack Waymire’s “Ch 8: Organization of Cell Types”
Link: The University of Texas’s Neuroscience Online: Dr. Jack Waymire’s “Ch 8: Organization of Cell Types” (HTML and Adobe Flash)
Instructions: Read the sections titled “Structural Variation” and “Naming Neurons.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Jack Waymire’s “Ch 8: Organization of Cell Types”
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10.1.3 Cortical Layers
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 26: Overview of the Cortical Structure”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 26: Overview of the Cortical Structure” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 26: Overview of the Cortical Structure”
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10.1.4 Cortical Lobes
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “The Lateral Surface of the Brain”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “The Lateral Surface of the Brain” (HTML)
Instructions: Read the entire webpage, and click on the hyperlinks to figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “The Lateral Surface of the Brain”
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10.1.5 Brodmann Areas
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 26: An Overview of Cortical Structure”
Link: NCBI Bookshelf’sversion of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 26: An Overview of Cortical Structure”
Instructions: Read the entire webpage, click on the embedded hyperlinks, and focus on the figures and tables.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: University of Michigan’s “Brodmann Area”
Link: University of Michigan’s “Brodmann Area” (HTML)
Instructions: Read the webpage, and view the figures of different views of the brain.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 26: An Overview of Cortical Structure”
- 10.2 Association
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10.2.1 Association Cortices
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: Ch 26: The Association Cortices: “Overview: The Association Cortices” and “The Association Cortices”
Links: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: Ch 26: The Association Cortices: “Overview: The Association Cortices” (HTML) and “The Association Cortices” (HTML)
Instructions: Read the webpages, and click on the hyperlink to Figure 26.1.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: Ch 26: The Association Cortices: “Overview: The Association Cortices” and “The Association Cortices”
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10.2.2 Cortical Input and Output Areas
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 26: Figure 26.3”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 26: Figure 26.3” (HTML)
Instructions: Study the linked figure.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 26: Figure 26.3”
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10.2.3 Contralateral Neglect Syndrome
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Lesions of the Parietal Association Cortex: Deficits of Attention”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Lesions of the Parietal Association Cortex: Deficits of Attention” (HTML)
Instructions: Read the entire webpage. Click on all hyperlinks to figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Lesions of the Parietal Association Cortex: Deficits of Attention”
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10.2.4 Deficits of Recognition and Planning
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Planning Neurons”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Planning Neurons” (HTML)
Instructions: Read the entire webpage, and click on all hyperlinks to figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Planning Neurons”
- 10.3 Speech and Language
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10.3.1 Broca’s Area
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 27: Aphasias”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 27: Aphasias” (HTML)
Instructions: Read the entire webpage. This resource also covers section 10.3.2.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 27: Aphasias”
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10.3.2 Aphasias
Note: This topic is covered by the reading beneath subunit 10.3.1.
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10.3.3 Wernicke’s Area
- Reading: Oracle ThinkQuest Education Foundation: “The Brain and Communication”
Link: Oracle ThinkQuest Education Foundation: “The Brain and Communication” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Oracle ThinkQuest Education Foundation: “The Brain and Communication”
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10.3.4 Vocal Folds and Speech
- Reading: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 8: Higher Cortical Functions: Language”
Link: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 8: Higher Cortical Functions: Language” (HTML and Adobe Flash)
Instructions: Read the paragraphs before the section titled “What Is language?”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 8: Higher Cortical Functions: Language”
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10.3.5 Right Hemisphere vs. Left Hemisphere
- Reading: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 9: Higher Cortical Functions: Association and Executive Processing”
Link: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 9: Higher Cortical Functions: Association and Executive Processing” (HTML and Adobe Flash)
Instructions: Read the entire webpage. The left hemisphere is dominant in reasoning and language while the right hemisphere dominant in visual and audio stimuli as well as artistic ability. Be sure to understand the differences between the two hemispheres as well as how they connect in the cortex.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. Nachum Dafny’s “Ch 9: Higher Cortical Functions: Association and Executive Processing”
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10.3.6 Sign Language
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Sign Language”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Sign Language” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Sign Language”
- 10.4 Sleep and Wakefulness
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10.4.1 Brain Changes during Sleep
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Thalamocortical Interactions”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Thalamocortical Interactions” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Thalamocortical Interactions”
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10.4.2 Stages of Sleep
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Stages of Sleep” and “The Possible Functions of REM Sleep and Dreaming”
Links: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Stages of Sleep” (HTML) and “The Possible Functions of REM Sleep and Dreaming” (HTML)
Instructions: Read both webpages in their entirety, and click on the hyperlinks for the figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Stages of Sleep” and “The Possible Functions of REM Sleep and Dreaming”
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10.4.3 Circadian Rhythm
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “The Circadian Cycle of Sleep and Wakefulness”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “The Circadian Cycle of Sleep and Wakefulness” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “The Circadian Cycle of Sleep and Wakefulness”
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10.4.4 Molecular Basis for Biological Clocks
- Reading: NCBI: PubMed – PNAS: Dr. Norio Ishida et al.’s “Biological Clocks”
Link: NCBI: PubMed – PNAS: Dr. Norio Ishida et al.’s “Biological Clocks” (HTML)
Instructions: Read the entire article.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI: PubMed – PNAS: Dr. Norio Ishida et al.’s “Biological Clocks”
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10.4.5 Neural Circuits of Sleep
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Neural Circuits Governing Sleep”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Neural Circuits Governing Sleep” (HTML)
Instructions: Read the entire webpage, and click on the hyperlinks for the figures.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Neural Circuits Governing Sleep”
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10.4.6 Drugs and Sleep
- Reading: WebMD: “Drug Treatment for Sleep Problems”
Link: WebMD: “Drug Treatment for Sleep Problems” (HTML)
Instructions: Read the entire article.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: WebMD: “Drug Treatment for Sleep Problems”
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10.4.7 Narcolepsy and Insomnia
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 28: Sleep Disorders”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 28: Sleep Disorders” (HTML)
Instructions: Read the paragraphs on “Insomnia” and “Narcolepsy.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 28: Sleep Disorders”
- 10.5 Emotion
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10.5.1 Autonomic System and Emotions
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 29: Physiological Changes Associated with Emotion”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 29: Physiological Changes Associated with Emotion” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 29: Physiological Changes Associated with Emotion”
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10.5.2 Limbic System
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 29: The Limbic System”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 29: The Limbic System” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 29: The Limbic System”
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10.5.3 Amygdala and Fear
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 29: The Importance of the Amygdala”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 29: The Importance of the Amygdala” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 29: The Importance of the Amygdala”
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10.5.4 Affective Disorders
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Box E - Affective Disorders”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Box E - Affective Disorders” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Box E - Affective Disorders”
- 10.6 Memory
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10.6.1 Declarative and Nondeclarative Memory
- Reading: The University of Texas’s Neuroscience Online: Dr. John Byrne’s “Ch 7: Learning and Memory”
Link: The University of Texas’s Neuroscience Online: Dr. John Byrne’s “Ch 7: Learning and Memory” (HTML and Adobe Flash)
Instructions: Read the entire webpage, and then take the quiz at the end of the page.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: The University of Texas’s Neuroscience Online: Dr. John Byrne’s “Ch 7: Learning and Memory”
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10.6.2 Immediate, Short-term, and Long-term Memory
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 31: Temporal Categories of Memory”
Link: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 31: Temporal Categories of Memory” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: “Ch 31: Temporal Categories of Memory”
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10.6.3 Consolidation and Association for Long-term Memory
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: Ch 31: “The Long-term Storage of Information” and “The Importance of Association in Information Storage”
Links: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: Ch 31: “The Long-term Storage of Information” (HTML) and “The Importance of Association in Information Storage” (HTML)
Instructions: Read both webpages in their entirety.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: NCBI Bookshelf’s version of Sinauer Associates, Inc., Purves, Augustine, Fitzpatrick, et al., editors’ Neuroscience, 2nd Edition: Ch 31: “The Long-term Storage of Information” and “The Importance of Association in Information Storage”
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10.6.4 Brain Structures Associated with Memory
- Reading: Canadian Institutes of Health Research: “The Brain from Top to Bottom: Short-term Memory”
Link: Canadian Institutes of Health Research: “The Brain from Top to Bottom: Short-term Memory” (HTML)
Instructions: Read the entire webpage, and click on hyperlinks on the webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: Canadian Institutes of Health Research: “The Brain from Top to Bottom: Short-term Memory”
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10.6.5 Forgetting and Amnesia
- Reading: BrainMaps.com: Neurological Disorders: “Amnesia”
Link: BrainMaps.com: Neurological Disorders: “Amnesia” (HTML)
Instructions: Read the entire webpage.
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Reading: BrainMaps.com: Neurological Disorders: “Amnesia”
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10.6.6 Alzheimer’s Disease
- Assessment: The Saylor Foundation’s “Unit 10 Assessment”
Link: The Saylor Foundation’s “Unit 10 Assessment” (PDF)
Instructions: Complete this quiz after working through Unit 10. The questions are either multiple choice, matching, or labeling diagrams. You can check your answers with the Saylor Foundation’s “Unit 10 Answer Key” (PDF).See a broken link? Please let us know!
- Lecture: Howard Hughes Medical Institute: Neuroscience Lecture Series -- 2008 Holiday Lectures: “Making Your Mind: Molecules, Motion, and Memory”
Link: Howard Hughes Medical Institute: Neuroscience Lecture Series -- 2008 Holiday Lectures: “Making Your Mind: Molecules, Motion, and Memory” (Adobe Flash or RealPlayer)
Instructions: In the 2008 Holiday Lectures section, click on the link to “Lecture 4 – Memories Are Made of This by Eric R. Kandel, M.D.” Then, on the right margin, click on “31. Aging, memory loss, and Alzheimer disease” and “32. The Alzheimer associated Aβ peptide is toxic to neurons.”
Terms of Use: Please respect the copyright and terms of use displayed on the webpage above.See a broken link? Please let us know!
- Assessment: The Saylor Foundation’s “Unit 10 Assessment”
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Final Exam
- Final Exam: The Saylor Foundation’s “BIO303 Final Exam”
Link: The Saylor Foundation’s “BIO303 Final Exam”
Instructions: You must be logged into your Saylor Foundation School account in order to access this exam. If you do not yet have an account, you will be able to create one, free of charge, after clicking the link.See a broken link? Please let us know!
- Final Exam: The Saylor Foundation’s “BIO303 Final Exam”
Questions? Consult the FAQ's!



